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Boerwinkle VL, Wilfong AA, Curry DJ. Resting-state functional connectivity by independent component analysis-based markers corresponds to areas of initial seizure propagation established by prior modalities from the hypothalamus. Brain Connect. 2016;6(8):642-651doi: 10.1089/brain.2015.0404.
Boerwinkle, V. L., Wilfong, A. A., & Curry, D. J. (2016). Resting-state functional connectivity by independent component analysis-based markers corresponds to areas of initial seizure propagation established by prior modalities from the hypothalamus. Brain connectivity, 6(8), 642-651. https://doi.org/10.1089/brain.2015.0404
Boerwinkle, Varina Louise, et al. "Resting-state functional connectivity by independent component analysis-based markers corresponds to areas of initial seizure propagation established by prior modalities from the hypothalamus." Brain connectivity vol. 6,8 (2016): 642-651. doi: https://doi.org/10.1089/brain.2015.0404
Boerwinkle VL, Wilfong AA, Curry DJ. Resting-state functional connectivity by independent component analysis-based markers corresponds to areas of initial seizure propagation established by prior modalities from the hypothalamus. Brain Connect. 2016 Oct;6(8):642-651. doi: 10.1089/brain.2015.0404. Epub 2016 Aug 08. PMID: 27503346; PMCID: PMC5069733.
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Brain Connect. 2016 Oct;6(8):642-651. doi: 10.1089/brain.2015.0404. Epub 2016 Aug 08.

Resting-state functional connectivity by independent component analysis-based markers corresponds to areas of initial seizure propagation established by prior modalities from the hypothalamus.

Brain connectivity

Varina Louise Boerwinkle, Angus A Wilfong, Daniel J Curry

Affiliations

  1. Baylor College of Medicine, 3989, Pediatric Neurology, Houston, Texas, United States ; [email protected].
  2. Baylor College of Medicine, Pediatrics, Houston, Texas, United States ; [email protected].
  3. Baylor College of Medicine, Neurosurgery, Houston, Texas, United States ; [email protected].

PMID: 27503346 PMCID: PMC5069733 DOI: 10.1089/brain.2015.0404

Abstract

OBJECTIVE: The aims of this study were to evaluate a clinically practical functional connectivity protocol designed to blindly identify the corresponding areas of initial seizure propagation and also to differentiate these areas from remote secondary areas affected by seizure. The patients in this cohort had intractable epilepsy caused by intrahypothalamic hamartoma, which is the location of the ictal focus. The ictal propagation pathway is homogeneous and established, thus creating the optimum situation for the proposed method validation study.

METHODS: Twelve patients with seizures from hypothalamic hamartoma and 6 normal control patients underwent resting state functional MRI, using independent component analysis to identify network differences in patients. This was followed by seed-based connectivity measures to determine the extent of functional connectivity derangement between hypothalamus and these areas. The areas with significant change in connectivity were compared with the results of prior studies' modalities used to evaluate seizure propagation.

RESULTS: The left amygdala-parahippocampal gyrus area, cingulate gyrus, and occipito-temporal gyrus demonstrated the highest derangement in connectivity with the hypothalamus, p < 0.01, corresponding to the initial seizure propagation areas established by prior modalities. Areas of secondary ictal propagation were differentiated from these initial locations by first being identified as an abnormal neuronal signal source via independent component analysis, but did not show significant connectivity directly with the known ictal focus.

CONCLUSION: Non-invasive connectivity measures correspond to areas of initial ictal propagation and differentiate such areas from secondary ictal propagation, which may aid in ictal focus surgical disconnection planning and support the use of this newer modality for adjunctive information in epilepsy surgery evaluation.

Keywords: Epilepsy; Functional connectivity; Independent component analysis (ICA); Partial seizures; Resting-state functional connectivity magnetic resonance imaging (R-fMRI)

Conflict of interest statement

Author Disclosure Statement No competing financial interests exist.

References

  1. Neuroimage. 2013 Feb 1;66:28-35 - PubMed
  2. Neuroimage. 2009 Oct 15;48(1):63-72 - PubMed
  3. Neuroimage. 2009 Jan 1;44(1):83-98 - PubMed
  4. Neuroimage. 2002 Oct;17(2):825-41 - PubMed
  5. Neuroimage. 2012 Aug 15;62(2):782-90 - PubMed
  6. Epilepsia. 2011 Jul;52 Suppl 4:38-42 - PubMed
  7. Ann Neurol. 1997 Jul;42(1):60-7 - PubMed
  8. PLoS One. 2013 Nov 12;8(11):e78796 - PubMed
  9. Radiology. 2010 Jul;256(1):229-37 - PubMed
  10. Neuroimage. 2011 Jan 1;54(1):313-27 - PubMed
  11. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13848-53 - PubMed
  12. AJNR Am J Neuroradiol. 2006 Apr;27(4):799-805 - PubMed
  13. Neurosci Biobehav Rev. 2013 Sep;37(8):1893-916 - PubMed
  14. IEEE Trans Med Imaging. 2004 Feb;23(2):137-52 - PubMed
  15. Med Image Anal. 2001 Jun;5(2):143-56 - PubMed
  16. Brain Connect. 2015 Feb;5(1):35-44 - PubMed
  17. Epilepsia. 2013 Dec;54 Suppl 9:109-14 - PubMed
  18. Brain Topogr. 2012 Jul;25(3):327-31 - PubMed
  19. Hum Brain Mapp. 2002 Jan;15(1):1-25 - PubMed
  20. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13040-5 - PubMed
  21. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20015-20 - PubMed
  22. J R Soc Interface. 2016 Jan;13(114):20151027 - PubMed
  23. Epileptic Disord. 2003 Dec;5(4):205-17 - PubMed
  24. Epilepsia. 2009 Jun;50(6):1624-31 - PubMed
  25. Cereb Cortex. 2010 Apr;20(4):953-65 - PubMed
  26. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7209-14 - PubMed
  27. Epilepsy Behav. 2003 Jun;4(3):246-58 - PubMed
  28. Neuroimage. 2012 Jan 2;59(1):168-80 - PubMed
  29. Neuroimage. 2011 Jul 1;57(1):198-205 - PubMed
  30. Neuroimage. 2012 Sep;62(3):1634-42 - PubMed
  31. Proc Natl Acad Sci U S A. 2015 May 19;112(20):6485-90 - PubMed
  32. Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):1001-13 - PubMed
  33. Brain Struct Funct. 2015 Jan;220(1):513-23 - PubMed
  34. Radiographics. 2008 Jul-Aug;28(4):1079-95 - PubMed

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