Display options
Cite
Milani P, Massacesi A, Moschini S, et al. Multimodal imaging and diagnosis of myopic choroidal neovascularization in Caucasians. Clin Ophthalmol. 2016;10:1749-57doi: 10.2147/OPTH.S108509.
Milani, P., Massacesi, A., Moschini, S., Setaccioli, M., Bulone, E., Tremolada, G., Ciaccia, S., Mantovani, E., Morale, D., & Bergamini, F. (2016). Multimodal imaging and diagnosis of myopic choroidal neovascularization in Caucasians. Clinical ophthalmology (Auckland, N.Z.), 101749-57. https://doi.org/10.2147/OPTH.S108509
Milani, Paolo, et al. "Multimodal imaging and diagnosis of myopic choroidal neovascularization in Caucasians." Clinical ophthalmology (Auckland, N.Z.) vol. 10 (2016): 1749-57. doi: https://doi.org/10.2147/OPTH.S108509
Milani P, Massacesi A, Moschini S, Setaccioli M, Bulone E, Tremolada G, Ciaccia S, Mantovani E, Morale D, Bergamini F. Multimodal imaging and diagnosis of myopic choroidal neovascularization in Caucasians. Clin Ophthalmol. 2016 Sep 12;10:1749-57. doi: 10.2147/OPTH.S108509. eCollection 2016. PMID: 27672306; PMCID: PMC5026213.
Copy Download .nbib Format: NLM
Share it on

Clin Ophthalmol. 2016 Sep 12;10:1749-57. doi: 10.2147/OPTH.S108509. eCollection 2016.

Multimodal imaging and diagnosis of myopic choroidal neovascularization in Caucasians.

Clinical ophthalmology (Auckland, N.Z.)

Paolo Milani, Amedeo Massacesi, Stefania Moschini, Marco Setaccioli, Ennio Bulone, Gemma Tremolada, Stefano Ciaccia, Elena Mantovani, Daniela Morale, Fulvio Bergamini

Affiliations

  1. Ophthalmology Department, Istituto Auxologico.
  2. Institute of Mathematics, Universita' degli Studi di Milano, Milan, Italy.

PMID: 27672306 PMCID: PMC5026213 DOI: 10.2147/OPTH.S108509

Abstract

PURPOSE: To investigate myopic choroidal neovascularization (mCNV) by fluorescein angiography (FA), spectral-domain optical coherence tomography (SD-OCT), near-infrared (NIR) reflectance, and autofluorescence (AF).

METHODS: This retrospective study included 65 eyes of 62 Caucasian patients with a mean age of 66.72 years (95% confidence interval [CI] 63-70 years) and a mean refraction of -9.72 diopters (95% CI -8.74 to -10.70 diopters).

RESULTS: Most of the mCNV cases were foveal-juxtafoveal (60/65, 92.3%), with thickening of the corresponding retina (62/65, 95.3%) and leakage on FA (44/65, 67.6%). No retinal fluid was detectable in 32 (49.2%) eyes and there was no hemorrhage in 25 (38.4%) eyes. Papillary chorioretinal atrophy was evident in 58 (89.2%), a shadowing effect in 48 (73.8%), and an epiretinal membrane in 38 (58.4%) eyes. If an area of macular chorioretinal atrophy was present, mCNV frequently developed adjacent to it and was hyperfluorescent rather than with leakage (P⩽0.001). In eyes with edema or hemorrhage, hyper-reflective foci were more frequent (P⩽0.005). NIR and AF features were indeterminable in 19 (29.2%) and 27 (41.5%) eyes, respectively. The predominant feature was black or grayish on NIR (34/65, 52.3%) and patchy (hypo- and hyperfluorescence was observed) on AF (25/65, 38.4%). FA and SD-OCT correctly detected mCNV in 49 (75.3%) and 48 (73.8%) eyes, respectively, whereas NIR and AF exhibited limited diagnostic sensitivity. Doubtful diagnosis was associated with hyperfluorescent mCNV (P⩽0.001), absence of retinal fluid and epiretinal membrane (P⩽0.05), and presence of macular chorioretinal atrophy (P⩽0.01).

CONCLUSION: Tomographic, angiographic, AF, and NIR features of mCNV are described in this study. Combination of SD-OCT and FA is recommendable for diagnosis.

Keywords: CNV; SD-OCT; fluorescein angiography; imaging; myopic neovascularization; pathologic myopia

References

  1. Ophthalmology. 2014 Jan;121(1):220-4 - PubMed
  2. Br J Ophthalmol. 2008 Sep;92(9):1236-40 - PubMed
  3. Am J Ophthalmol. 2009 Jul;148(1):79-82.e2 - PubMed
  4. Surv Ophthalmol. 2012 Nov;57(6):498-509 - PubMed
  5. Am J Ophthalmol. 2013 May;155(5):913-9 - PubMed
  6. Graefes Arch Clin Exp Ophthalmol. 2013 Aug;251(8):1891-900 - PubMed
  7. Acta Ophthalmol Scand. 2002 Feb;80(1):82-7 - PubMed
  8. Am J Ophthalmol. 2009 Apr;147(4):621-626.e1 - PubMed
  9. Am J Ophthalmol. 2015 Aug;160(2):322-327.e2 - PubMed
  10. Retina. 2012 May;32(5):949-55 - PubMed
  11. Br J Ophthalmol. 2003 Sep;87(9):1088-90 - PubMed
  12. Retina. 2014 Jan;34(1):48-54 - PubMed
  13. Ophthalmology. 1993 Sep;100(9):1384-8 - PubMed
  14. Clin Exp Ophthalmol. 2009 Jan;37(1):130-43 - PubMed
  15. Br J Ophthalmol. 2009 Jun;93(6):771-4 - PubMed
  16. Ophthalmologica. 2014;232(1):28-36 - PubMed
  17. Ophthalmology. 2010 Aug;117(8):1595-611, 1611.e1-4 - PubMed
  18. Acta Ophthalmol Scand. 2007 Feb;85(1):50-4 - PubMed
  19. Am J Ophthalmol. 2008 Aug;146(2):218-227 - PubMed
  20. Br J Ophthalmol. 2009 Feb;93(2):182-5 - PubMed
  21. Ophthalmology. 2009 May;116(5):914-20 - PubMed
  22. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5965-9 - PubMed
  23. Am J Ophthalmol. 2007 Nov;144(5):741-746 - PubMed
  24. Br J Ophthalmol. 2012 Aug;96(8):1068-72 - PubMed
  25. Ophthalmology. 1996 Jan;103(1):58-71 - PubMed
  26. Ophthalmology. 1984 Dec;91(12):1573-81 - PubMed
  27. Vision Res. 1996 Jan;36(1):191-205 - PubMed
  28. Am J Ophthalmol. 2014 Jan;157(1):9-25.e12 - PubMed
  29. Retina. 2013 Jul-Aug;33(7):1375-92 - PubMed
  30. Am J Ophthalmol. 2013 Jun;155(6):991-999.e1 - PubMed
  31. Ophthalmic Surg Lasers Imaging Retina. 2013 Mar-Apr;44(2):140-4 - PubMed

Publication Types