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Li WX, Dai SX, Wang Q, et al. Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets. PeerJ. 2016;4:e2470doi: 10.7717/peerj.2470.
Li, W. X., Dai, S. X., Wang, Q., Guo, Y. C., Hong, Y., Zheng, J. J., Liu, J. Q., Liu, D., Li, G. H., & Huang, J. F. (2016). Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets. PeerJ, 4e2470. https://doi.org/10.7717/peerj.2470
Li, Wen-Xing, et al. "Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets." PeerJ vol. 4 (2016): e2470. doi: https://doi.org/10.7717/peerj.2470
Li WX, Dai SX, Wang Q, Guo YC, Hong Y, Zheng JJ, Liu JQ, Liu D, Li GH, Huang JF. Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets. PeerJ. 2016 Sep 15;4:e2470. doi: 10.7717/peerj.2470. eCollection 2016. PMID: 27672514; PMCID: PMC5028792.
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PeerJ. 2016 Sep 15;4:e2470. doi: 10.7717/peerj.2470. eCollection 2016.

Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets.

PeerJ

Wen-Xing Li, Shao-Xing Dai, Qian Wang, Yi-Cheng Guo, Yi Hong, Jun-Juan Zheng, Jia-Qian Liu, Dahai Liu, Gong-Hua Li, Jing-Fei Huang

Affiliations

  1. Institute of Health Sciences, Anhui University, Hefei, Anhui, China.
  2. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
  3. Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
  4. Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei, Anhui, China.
  5. KIZ-SU Joint Laboratory of Animal Models and Drug Development, College of Pharmaceutical Sciences, Soochow University, Kunming, Yunnan, China.
  6. Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan, Kunming, Yunnan, China.

PMID: 27672514 PMCID: PMC5028792 DOI: 10.7717/peerj.2470

Abstract

Ischemic stroke is a common neurological disorder and the burden in the world is growing. This study aims to explore the effect of sex and age difference on ischemic stroke using integrated microarray datasets. The results showed a dramatic difference in whole gene expression profiles and influenced pathways between males and females, and also in the old and young individuals. Furthermore, compared with old males, old female patients showed more serious biological function damage. However, females showed less affected pathways than males in young subjects. Functional interaction networks showed these differential expression genes were mostly related to immune and inflammation-related functions. In addition, we found ARG1 and MMP9 were up-regulated in total and all subgroups. Importantly, IL1A, ILAB, IL6 and TNF and other anti-stroke target genes were up-regulated in males. However, these anti-stroke target genes showed low expression in females. This study found huge sex and age differences in ischemic stroke especially the opposite expression of anti-stroke target genes. Future studies are needed to uncover these pathological mechanisms, and to take appropriate pre-prevention, treatment and rehabilitation measures.

Keywords: Anti-stroke target; Ischemic stroke; Sex and age difference

Conflict of interest statement

The authors declare there are no competing interests.

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