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Malik S, Mallick B, Makkar K, et al. Malignant McKittrick-Wheelock syndrome as a cause of acute kidney injury and hypokalemia: Report of a case and review of literature. Intractable Rare Dis Res. 2016;5(3):218-21doi: 10.5582/irdr.2016.01011.
Malik, S., Mallick, B., Makkar, K., Kumar, V., Sharma, V., & Rana, S. S. (2016). Malignant McKittrick-Wheelock syndrome as a cause of acute kidney injury and hypokalemia: Report of a case and review of literature. Intractable & rare diseases research, 5(3), 218-21. https://doi.org/10.5582/irdr.2016.01011
Malik, Sarthak, et al. "Malignant McKittrick-Wheelock syndrome as a cause of acute kidney injury and hypokalemia: Report of a case and review of literature." Intractable & rare diseases research vol. 5,3 (2016): 218-21. doi: https://doi.org/10.5582/irdr.2016.01011
Malik S, Mallick B, Makkar K, Kumar V, Sharma V, Rana SS. Malignant McKittrick-Wheelock syndrome as a cause of acute kidney injury and hypokalemia: Report of a case and review of literature. Intractable Rare Dis Res. 2016 Aug;5(3):218-21. doi: 10.5582/irdr.2016.01011. PMID: 27672546; PMCID: PMC4995412.
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Intractable Rare Dis Res. 2016 Aug;5(3):218-21. doi: 10.5582/irdr.2016.01011.

Malignant McKittrick-Wheelock syndrome as a cause of acute kidney injury and hypokalemia: Report of a case and review of literature.

Intractable & rare diseases research

Sarthak Malik, Bipadabhanjan Mallick, Kunaal Makkar, Vivek Kumar, Vishal Sharma, Surinder Singh Rana

Affiliations

  1. Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  2. Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  3. Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

PMID: 27672546 PMCID: PMC4995412 DOI: 10.5582/irdr.2016.01011

Abstract

Colonic polyps are usually asymptomatic, and are commonly detected during screening colonoscopy. Severe hypokalemia secondary to secretory diarrhea is a rare presentation of rectal polyps. We present a 70 years old female with hypokalemia and acute kidney injury secondary to secretory diarhea due to moderately differentiated adenocarcinoma of rectum, all of which is syndromically sometimes referred to as McKittrick and Wheelock syndrome. The case is presented because McKittrick-Wheelock syndrome is still more uncommon with malignancy. The syndrome may be associated with other features of hypersecretory diarrhea. Though very rare, clinical suspicion would often lead to diagnosis and appropriate management. We also review the previously published reports of this entity.

Keywords: Diarrhea; colorectal cancer; hypokalemia; rectal adenoma

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