Display options
Cite
Carballo-Villalobos AI, González-Trujano ME, Pellicer F, et al. Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain. Biomed Res Int. 2016;2016:8263463doi: 10.1155/2016/8263463.
Carballo-Villalobos, A. I., González-Trujano, M. E., Pellicer, F., & López-Muñoz, F. J. (2016). Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain. BioMed research international, 20168263463. https://doi.org/10.1155/2016/8263463
Carballo-Villalobos, Azucena I, et al. "Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain." BioMed research international vol. 2016 (2016): 8263463. doi: https://doi.org/10.1155/2016/8263463
Carballo-Villalobos AI, González-Trujano ME, Pellicer F, López-Muñoz FJ. Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain. Biomed Res Int. 2016;2016:8263463. doi: 10.1155/2016/8263463. Epub 2016 Sep 08. PMID: 27672659; PMCID: PMC5031820.
Copy Download .nbib Format: NLM
Share it on

Biomed Res Int. 2016;2016:8263463. doi: 10.1155/2016/8263463. Epub 2016 Sep 08.

Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain.

BioMed research international

Azucena I Carballo-Villalobos, María-Eva González-Trujano, Francisco Pellicer, Francisco J López-Muñoz

Affiliations

  1. Laboratorio No. 7 "Dolor y Analgesia" del Departamento de Farmacobiología, Cinvestav-Sede Sur, Calz. de los Tenorios No. 235, Col. Granjas Coapa, CP 14330, México, DF, Mexico; Laboratorio de Neurofarmacología de Productos Naturales de la Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Av. México-Xochimilco No. 101, Col. San Lorenzo Huipulco 14370, México, DF, Mexico.
  2. Laboratorio de Neurofarmacología de Productos Naturales de la Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Av. México-Xochimilco No. 101, Col. San Lorenzo Huipulco 14370, México, DF, Mexico.
  3. Laboratorio No. 7 "Dolor y Analgesia" del Departamento de Farmacobiología, Cinvestav-Sede Sur, Calz. de los Tenorios No. 235, Col. Granjas Coapa, CP 14330, México, DF, Mexico.

PMID: 27672659 PMCID: PMC5031820 DOI: 10.1155/2016/8263463

Abstract

Neuropathic pain is caused by a primary lesion, dysfunction, or transitory perturbation in the peripheral or central nervous system. In this study, we investigated the hesperidin antihyperalgesic effects alone or combined with diosmin in a model of neuropathic pain to corroborate a possible synergistic antinociceptive activity. Mechanical and thermal hyperalgesia were assessed in the aesthesiometer and plantar tests, respectively, after chronic constriction injury (CCI) model in rats receiving hesperidin (HS, 5 doses from 10 to 1000 mg/kg) alone or combined with diosmin (DS, 10 and 100 mg/kg) in comparison to gabapentin (31.6 mg/kg). UHPLC-MS analysis of cerebral samples was used to recognize the central concentrations of these flavonoids. Participation of different receptors was also investigated in the presence of haloperidol, bicuculline, and naloxone antagonists. Acute hesperidin administration significantly decreased mechanical and thermal hyperalgesia in CCI rats. Antihyperalgesic response of hesperidin, improved by a combination with diosmin (DS10/HS100) in both stimuli, was blockaded by haloperidol, bicuculline, and naloxone, but not WAY100635, antagonists. Both flavonoids were detected in brain samples. In conclusion, hesperidin alone and combined with diosmin produces antihyperalgesic response in the CCI model in rats. Antihyperalgesic effect of DS10/HS100 combination involves central activity partially modulated by D

References

  1. Folia Med Cracov. 1987;28(3-4):283-303 - PubMed
  2. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:103-9 - PubMed
  3. Biomed Res Int. 2014;2014:249031 - PubMed
  4. J Agric Food Chem. 2008 Aug 13;56(15):6185-205 - PubMed
  5. J Physiol Pharmacol. 2002 Dec;53(4 Pt 1):571-84 - PubMed
  6. Sci Rep. 2015 Mar 12;5:9043 - PubMed
  7. Pharmacol Biochem Behav. 2014 Sep;124:101-7 - PubMed
  8. Angiology. 1994 Jun;45(6 Pt 2):579-84 - PubMed
  9. Angiology. 1994 Jun;45(6 Pt 2):554-9 - PubMed
  10. Arzneimittelforschung. 1987 Oct;37(10):1149-53 - PubMed
  11. Pharmacol Biochem Behav. 2011 Feb;97(4):683-9 - PubMed
  12. Biochem Pharmacol. 2006 Dec 15;72(12):1707-13 - PubMed
  13. Mol Pain. 2011 Dec 15;7:97 - PubMed
  14. BMJ. 2014 Feb 05;348:f7656 - PubMed
  15. Pharm Biol. 2014 Jul;52(7):814-28 - PubMed
  16. Eur J Pharmacol. 2006 Jun 13;539(3):168-76 - PubMed
  17. Lille Med. 1980 Oct;25(8):470-2 - PubMed
  18. Phlebologie. 1973 Apr-Jun;26(2):263-72 - PubMed
  19. J Pharmacol Sci. 2014;124(3):313-9 - PubMed
  20. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Sep;27(6):1001-5 - PubMed
  21. Eur J Pain. 2010 Nov;14(10):992-8 - PubMed
  22. Adv Pharmacol. 2006;54:1-27 - PubMed
  23. Biomed Chromatogr. 2009 Feb;23(2):124-31 - PubMed
  24. Behav Brain Res. 2005 Mar 30;158(2):191-9 - PubMed
  25. Pharmacol Biochem Behav. 2014 Oct;125:78-84 - PubMed
  26. Pol J Pharmacol Pharm. 1984 Sep-Oct;36(5):455-63 - PubMed
  27. Zhong Xi Yi Jie He Xue Bao. 2012 Dec;10(12):1482-9 - PubMed
  28. J Diabetes Complications. 2012 Nov-Dec;26(6):483-90 - PubMed
  29. Toxicol Ind Health. 2015 Sep;31(9):841-51 - PubMed
  30. Int J Clin Pharmacol Ther Toxicol. 1992 Jan;30(1):29-33 - PubMed
  31. Pain. 1988 Jan;32(1):89-94 - PubMed
  32. Altern Med Rev. 2004 Sep;9(3):308-11 - PubMed
  33. Eur J Pharmacol. 2008 Feb 12;580(3):306-13 - PubMed
  34. Planta Med. 2009 Mar;75(4):295-301 - PubMed
  35. Pain. 2008 Jun;136(3):380-7 - PubMed
  36. Pain. 1988 Apr;33(1):87-107 - PubMed
  37. Pharmacol Biochem Behav. 2005 Jan;80(1):93-108 - PubMed
  38. Brain Res. 2011 Oct 28;1420:93-105 - PubMed
  39. Ann N Y Acad Sci. 2009 Sep;1173:798-804 - PubMed
  40. Pain. 1988 Jan;32(1):77-88 - PubMed
  41. Eur J Pharmacol. 2011 Jan 15;650(2-3):694-702 - PubMed
  42. Pain. 2004 Jun;109(3):379-88 - PubMed
  43. Eur J Pharmacol. 2004 Jan 26;484(2-3):157-65 - PubMed
  44. J Neurochem. 2008 Oct;107(1):230-40 - PubMed

Publication Types