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Howard AC, Rollins J, Snow S, et al. Reducing translation through eIF4G/IFG-1 improves survival under ER stress that depends on heat shock factor HSF-1 in Caenorhabditis elegans. Aging Cell. 2016;15(6):1027-1038doi: 10.1111/acel.12516.
Howard, A. C., Rollins, J., Snow, S., Castor, S., & Rogers, A. N. (2016). Reducing translation through eIF4G/IFG-1 improves survival under ER stress that depends on heat shock factor HSF-1 in Caenorhabditis elegans. Aging cell, 15(6), 1027-1038. https://doi.org/10.1111/acel.12516
Howard, Amber C, et al. "Reducing translation through eIF4G/IFG-1 improves survival under ER stress that depends on heat shock factor HSF-1 in Caenorhabditis elegans." Aging cell vol. 15,6 (2016): 1027-1038. doi: https://doi.org/10.1111/acel.12516
Howard AC, Rollins J, Snow S, Castor S, Rogers AN. Reducing translation through eIF4G/IFG-1 improves survival under ER stress that depends on heat shock factor HSF-1 in Caenorhabditis elegans. Aging Cell. 2016 Dec;15(6):1027-1038. doi: 10.1111/acel.12516. Epub 2016 Aug 18. PMID: 27538368; PMCID: PMC5114698.
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Aging Cell. 2016 Dec;15(6):1027-1038. doi: 10.1111/acel.12516. Epub 2016 Aug 18.

Reducing translation through eIF4G/IFG-1 improves survival under ER stress that depends on heat shock factor HSF-1 in Caenorhabditis elegans.

Aging cell

Amber C Howard, Jarod Rollins, Santina Snow, Sarah Castor, Aric N Rogers

Affiliations

  1. MDI Biological Laboratory, Davis Center for Regenerative Biology and Medicine, 159 Old Bar Harbor Road, Salisbury Cove, ME, 04672, USA.
  2. The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.

PMID: 27538368 PMCID: PMC5114698 DOI: 10.1111/acel.12516

Abstract

Although certain methods of lowering and/or altering mRNA translation are associated with increased lifespan, the mechanisms underlying this effect remain largely unknown. We previously showed that the increased lifespan conferred by reducing expression of eukaryotic translation initiation factor 4G (eIF4G/IFG-1) enhances survival under starvation conditions while shifting protein expression toward factors involved with maintaining ER-dependent protein and lipid balance. In this study, we investigated changes in ER homeostasis and found that lower eIF4G/IFG-1 increased survival under conditions of ER stress. Enhanced survival required the ER stress sensor gene ire-1 and the ER calcium ATPase gene sca-1 and corresponded with increased translation of chaperones that mediate the ER unfolded protein response (UPR

© 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Keywords: Caenorhabditis elegans ; ifg-1 ; eIF4G; healthspan; lifespan; proteostasis

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