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Chemistry. 2016 Nov 07;22(46):16586-16597. doi: 10.1002/chem.201604107. Epub 2016 Oct 05.

Hierarchical Analysis of Self-Assembled PEGylated Hexaphenylalanine Photoluminescent Nanostructures.

Chemistry (Weinheim an der Bergstrasse, Germany)

Carlo Diaferia, Teresa Sibillano, Nicole Balasco, Cinzia Giannini, Valentina Roviello, Luigi Vitagliano, Giancarlo Morelli, Antonella Accardo

Affiliations

  1. Department of Pharmacy, Research Centre on Bioactive Peptides (CIRPeB), University of Naples "Federico II" and DFM Scarl, Via Mezzocannone 16, 80134, Naples, Italy.
  2. Institute of Crystallography (IC), CNR, Via Amendola 122, 70126, Bari, Italy.
  3. Institute of Biostructures and Bioimaging (IBB), CNR, Via Mezzocannone 16, 80134, Naples, Italy.
  4. Regional Center of Competence Technologies Scarl, Via Nuova Agnano, 11, 80125, Naples, Italy.
  5. Department of Pharmacy, Research Centre on Bioactive Peptides (CIRPeB), University of Naples "Federico II" and DFM Scarl, Via Mezzocannone 16, 80134, Naples, Italy. [email protected].

PMID: 27706842 DOI: 10.1002/chem.201604107

Abstract

Despite the growing literature about diphenylalanine-based peptide materials, it still remains a challenge to delineate the theoretical insight into peptide nanostructure formation and the structural features that could permit materials with enhanced properties to be engineered. Herein, we report the synthesis of a novel peptide building block composed of six phenylalanine residues and eight PEG units, PEG

© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords: diphenylalanine; molecular dynamics; nanostructures; peptide materials; photoluminescence

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