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Yamabata S, Shiraishi H, Munechika M, et al. Effects of electrical stimulation therapy on the blood flow in chronic critical limb ischemia patients following regenerative therapy. SAGE Open Med. 2016;4:2050312116660723doi: 10.1177/2050312116660723.
Yamabata, S., Shiraishi, H., Munechika, M., Fukushima, H., Fukuoka, Y., Hojo, T., Shirayama, T., Horii, M., Matoba, S., & Kubo, T. (2016). Effects of electrical stimulation therapy on the blood flow in chronic critical limb ischemia patients following regenerative therapy. SAGE open medicine, 42050312116660723. https://doi.org/10.1177/2050312116660723
Yamabata, Shiho, et al. "Effects of electrical stimulation therapy on the blood flow in chronic critical limb ischemia patients following regenerative therapy." SAGE open medicine vol. 4 (2016): 2050312116660723. doi: https://doi.org/10.1177/2050312116660723
Yamabata S, Shiraishi H, Munechika M, Fukushima H, Fukuoka Y, Hojo T, Shirayama T, Horii M, Matoba S, Kubo T. Effects of electrical stimulation therapy on the blood flow in chronic critical limb ischemia patients following regenerative therapy. SAGE Open Med. 2016 Jul 22;4:2050312116660723. doi: 10.1177/2050312116660723. eCollection 2016. PMID: 27504185; PMCID: PMC4962517.
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SAGE Open Med. 2016 Jul 22;4:2050312116660723. doi: 10.1177/2050312116660723. eCollection 2016.

Effects of electrical stimulation therapy on the blood flow in chronic critical limb ischemia patients following regenerative therapy.

SAGE open medicine

Shiho Yamabata, Hirokazu Shiraishi, Mai Munechika, Hideki Fukushima, Yoshiyuki Fukuoka, Tatsuya Hojo, Takeshi Shirayama, Motoyuki Horii, Satoaki Matoba, Toshikazu Kubo

Affiliations

  1. Rehabilitation Unit, University Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  2. Rehabilitation Unit, University Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  3. Graduate School of Health and Sports Science, Doshisha University, Kyoto, Japan.
  4. Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  5. Rehabilitation Unit, University Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

PMID: 27504185 PMCID: PMC4962517 DOI: 10.1177/2050312116660723

Abstract

OBJECTIVES: We investigated the effects of electrical stimulation therapy on cutaneous and muscle blood flow in critical limb ischemia patients following regenerative therapy.

METHODS: Three groups were studied: 10 healthy young subjects, 10 elderly subjects, and 7 critical limb ischemia patients after regenerative therapy. After 5 min rest, electrical stimulation was applied at 5 Hz on the tibialis anterior muscle for 10 min. We estimated the relative changes in oxyhemoglobin and total hemoglobin compared to the basal values at rest (Δ[HbO2], Δ[Hbtot]), which reflected the blood flow in the skin and muscle layer, and we simultaneously measured the tissue O2 saturation (StO2) throughout the electrical stimulation and recovery phase by near-infrared spectroscopy.

RESULTS: The Δ[HbO2] and Δ[Hbtot] values of the muscle layer in critical limb ischemia patients increased gradually and remained significantly higher at the 5-min and 10-min recovery periods after the electrical stimulation without reducing the StO2, but there is no significant change in the other two groups. Skin blood flow was not influenced by electrical stimulation in three groups.

CONCLUSION: This improvement of the peripheral circulation by electrical stimulation would be beneficial as the adjunctive therapy after regenerative cell therapy.

Keywords: Critical limb ischemia; electrical stimulation; hemoglobin; near-infrared spectroscopy; regenerative cell therapy

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