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Akpinar A, Ucler N, Erdogan U, et al. Measuring serum matrix metalloproteinase-9 levels in peripheral blood after subarachnoid hemorrhage to predict cerebral vasospasm. Springerplus. 2016;5(1):1153doi: 10.1186/s40064-016-2837-6.
Akpinar, A., Ucler, N., Erdogan, U., Baydin, S. S., Gungor, A., & Tugcu, B. (2016). Measuring serum matrix metalloproteinase-9 levels in peripheral blood after subarachnoid hemorrhage to predict cerebral vasospasm. SpringerPlus, 5(1), 1153. https://doi.org/10.1186/s40064-016-2837-6
Akpinar, Aykut, et al. "Measuring serum matrix metalloproteinase-9 levels in peripheral blood after subarachnoid hemorrhage to predict cerebral vasospasm." SpringerPlus vol. 5,1 (2016): 1153. doi: https://doi.org/10.1186/s40064-016-2837-6
Akpinar A, Ucler N, Erdogan U, Baydin SS, Gungor A, Tugcu B. Measuring serum matrix metalloproteinase-9 levels in peripheral blood after subarachnoid hemorrhage to predict cerebral vasospasm. Springerplus. 2016 Jul 22;5(1):1153. doi: 10.1186/s40064-016-2837-6. eCollection 2016. PMID: 27504251; PMCID: PMC4958081.
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Springerplus. 2016 Jul 22;5(1):1153. doi: 10.1186/s40064-016-2837-6. eCollection 2016.

Measuring serum matrix metalloproteinase-9 levels in peripheral blood after subarachnoid hemorrhage to predict cerebral vasospasm.

SpringerPlus

Aykut Akpinar, Necati Ucler, Uzay Erdogan, Serhat S Baydin, Abuzer Gungor, Bekir Tugcu

Affiliations

  1. Department of Neurosurgery, Adiyaman University Education and Research Hospital, 02200 Adiyaman, Turkey.
  2. Bakirkoy Research and Training Hospital for Neurology Neurosurgery and Psychiatry, Istanbul, Turkey.
  3. Department of Neurosurgery, Mcknight Brain Institute, University of Florida, Gainesville, FL USA.

PMID: 27504251 PMCID: PMC4958081 DOI: 10.1186/s40064-016-2837-6

Abstract

PURPOSE: We aimed to investigate serum levels of matrix metalloproteinase-9 in both subarachnoid hemorrhage and control groups for prediction of cerebral vasospasm in this study.

METHODS: Venous serum matrix metalloproteinase-9 levels were prospectively measured four times (days 1, 3, 7, and 14) for 34 consecutive patients with subarachnoidal hemorrhage (n = 27) and for elective aneurysm clipping (control, n = 7).

RESULTS: Vasospasm developed in 11/34 (32.4 %) patients between 3 and 10 days after subarachnoid hemorrhage (median 5.58 days), mean peak serum matrix metalloproteinase-9 compared with the non-vasospasm cohort. Matrix metalloproteinase-9 levels were higher in subarachnoid hemorrhage patients than in the controls.

CONCLUSION: Increased serum matrix metalloproteinase-9 could be an accurate biomarker to predict the onset of cerebral vasospasm after subarachnoid hemorrhage.

Keywords: Aneurysm; Ischemia; Matrix metalloproteinase-9; Subarachnoid hemorrhage

References

  1. Brain Res. 2015 Oct 22;1624:113-24 - PubMed
  2. Stroke. 2015 Oct;46(10 ):2909-15 - PubMed
  3. Stroke. 1987 Mar-Apr;18(2):365-72 - PubMed
  4. Stroke. 1998 Aug;29(8):1580-3 - PubMed
  5. Br J Neurosurg. 1995;9(3):403-12 - PubMed
  6. J Neurol Sci. 2006 Dec 21;251(1-2):82-6 - PubMed
  7. Neurosurgery. 1980 Jan;6(1):1-9 - PubMed
  8. Neurol Res. 2015 Aug;37(8):688-92 - PubMed
  9. Neurosurgery. 1992 Jan;30(1):12-6 - PubMed
  10. Neurosurgery. 1990 Nov;27(5):729-39; discussion 739-40 - PubMed
  11. Stroke. 1988 Oct;19(10):1300-5 - PubMed
  12. Acta Neuropathol. 1991;81(4):401-7 - PubMed
  13. Surg Neurol. 1986 Apr;25(4):317-25 - PubMed
  14. Stroke. 2001 Aug;32(8):1759-66 - PubMed

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