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Grover S, Selhi PK, Sood N, et al. Non-Secretory Myeloma, Diagnosed on Renal Biopsy as Cast Nephropathy. J Clin Diagn Res. 2016;10(6):ED04-5doi: 10.7860/JCDR/2016/19060.7925.
Grover, S., Selhi, P. K., Sood, N., Sandhu, J. S., & Kaur, H. (2016). Non-Secretory Myeloma, Diagnosed on Renal Biopsy as Cast Nephropathy. Journal of clinical and diagnostic research : JCDR, 10(6), ED04-5. https://doi.org/10.7860/JCDR/2016/19060.7925
Grover, Sumit, et al. "Non-Secretory Myeloma, Diagnosed on Renal Biopsy as Cast Nephropathy." Journal of clinical and diagnostic research : JCDR vol. 10,6 (2016): ED04-5. doi: https://doi.org/10.7860/JCDR/2016/19060.7925
Grover S, Selhi PK, Sood N, Sandhu JS, Kaur H. Non-Secretory Myeloma, Diagnosed on Renal Biopsy as Cast Nephropathy. J Clin Diagn Res. 2016 Jun;10(6):ED04-5. doi: 10.7860/JCDR/2016/19060.7925. Epub 2016 Jun 01. PMID: 27504298; PMCID: PMC4963658.
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J Clin Diagn Res. 2016 Jun;10(6):ED04-5. doi: 10.7860/JCDR/2016/19060.7925. Epub 2016 Jun 01.

Non-Secretory Myeloma, Diagnosed on Renal Biopsy as Cast Nephropathy.

Journal of clinical and diagnostic research : JCDR

Sumit Grover, Pavneet Kaur Selhi, Neena Sood, Jasvinder Singh Sandhu, Harpreet Kaur

Affiliations

  1. Assistant Professor, Department of Pathology, Dayanand Medical College and Hospital , Ludhiana, Punjab, India .
  2. Professor, Department of Pathology, Dayanand Medical College and Hospital , Ludhiana, Punjab, India .
  3. Professor and Head, Department of Pathology, Dayanand Medical College and Hospital , Ludhiana, Punjab, India .
  4. Professor and Head, Department of Nephrology, Dayanand Medical College and Hospital , Ludhiana, Punjab, India .

PMID: 27504298 PMCID: PMC4963658 DOI: 10.7860/JCDR/2016/19060.7925

Abstract

Multiple myeloma is a disorder of plasma cells which can involve kidneys in the form of cast nephropathy. Neoplastic plasma cells produce either complete immunoglobulins or fragments of immunoglobulins leading to a monoclonal spike in the serum and/or Bence Jones proteinuria. Very few patients present as non-secretory myeloma when no immunoglobulins (M spike) are produced or only light chains are secreted which can only be detected in urine. Acute renal failure due to cast nephropathy can rarely be the first presentation of multiple myeloma. We here in report a case in which primary diagnosis of multiple myeloma was made on renal biopsy due to its characteristic histomorphology. The diagnosis was later on supported by presence of neoplastic plasma cells in the aspirate and biopsy of bone marrow.

Keywords: Fractured casts; Kidney biopsy; Plasma cell dyscrasia; Protein electrophoresis; Renal failure

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