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El-Bahrawy A, Tarhuni A, Kim H, et al. ApoE deficiency promotes colon inflammation and enhances inflammatory potential oxidized-LDL and TNF-α in colon epithelial cells. Biosci Rep. 2016;36(5)doi: 10.1042/BSR20160195.
El-Bahrawy, A., Tarhuni, A., Kim, H., Subramaniam, V., Benslimane, I., Abd Elmageed, Z. Y., Okpechi, S., Ghonim, M., Hemeida, R., Abo-Yousef, A., El-Sherbiny, G., Abdel-Raheem, I., Kim, J., Naura, A. S., & Boulares, H. (2016). ApoE deficiency promotes colon inflammation and enhances inflammatory potential oxidized-LDL and TNF-α in colon epithelial cells. Bioscience reports, 36(5), . https://doi.org/10.1042/BSR20160195
El-Bahrawy, Ali, et al. "ApoE deficiency promotes colon inflammation and enhances inflammatory potential oxidized-LDL and TNF-α in colon epithelial cells." Bioscience reports vol. 36,5 (2016). doi: https://doi.org/10.1042/BSR20160195
El-Bahrawy A, Tarhuni A, Kim H, Subramaniam V, Benslimane I, Abd Elmageed ZY, Okpechi S, Ghonim M, Hemeida R, Abo-Yousef A, El-Sherbiny G, Abdel-Raheem I, Kim J, Naura AS, Boulares H. ApoE deficiency promotes colon inflammation and enhances inflammatory potential oxidized-LDL and TNF-α in colon epithelial cells. Biosci Rep. 2016 Oct;36(5). doi: 10.1042/BSR20160195. Epub 2016 Aug 18. PMID: 27538678; PMCID: PMC5052706.
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Biosci Rep. 2016 Oct;36(5). doi: 10.1042/BSR20160195. Epub 2016 Aug 18.

ApoE deficiency promotes colon inflammation and enhances inflammatory potential oxidized-LDL and TNF-α in colon epithelial cells.

Bioscience reports

Ali El-Bahrawy, Abdelmetalab Tarhuni, Hogyoung Kim, Venkat Subramaniam, Ilyes Benslimane, Zakaria Y Abd Elmageed, Samuel Okpechi, Mohamed Ghonim, Ramadan Hemeida, Amira Abo-Yousef, Gamal El-Sherbiny, Ihab Abdel-Raheem, Jong Kim, Amarjit S Naura, Hamid Boulares

Affiliations

  1. LSUHSC, 1700 Tulane Ave, Kenner, Louisiana, 70065, United States.
  2. The Stanley Scott Cancer Center, LSU Health Science Center, 533 Bolivar St, New Orleans, Louisiana, 70112, United States.
  3. Tulane Univ, 1700 Tulane Ave, New Orleans, Louisiana, 70112, United States.
  4. Al-Azhar Un iversity, Assiut, Egypt.
  5. Al-Azhar Un iversity, Beni-Suef City, Arizona, Egypt.
  6. Al-Azhar Un iversity, Kafr El-Sheikh, Egypt.
  7. LSUHSC, 1700 Tulane Ave, Kenner, Louisiana, 70065, United States [email protected].

PMID: 27538678 PMCID: PMC5052706 DOI: 10.1042/BSR20160195

Abstract

Although deficiency in Apolipoprotein E (ApoE) is linked to many diseases, its effect on colon homeostasis remains unknown.  ApoE appears to control inflammation by regulating NF-kB.  This study was designed to examine whether ApoE deficiency affects factors of colon integrity in vivo and given the likelihood that ApoE deficiency increases oxidized lipids and TNF-α, this study also examined whether such deficiency enhances the inflammatory potential of oxidized-LDL (oxLDL) and TNF-α, in colon epithelial cells in vitro   Here we show that ApoE deficiency is associated with chronic inflammation systemically and in colonic tissues as assessed by TNF-α levels.  Increased colon TNF-α mRNA coincided with a substantial increase in cyclooxygenase (COX)-2.  ApoE deficiency enhanced the potential of oxLDL and TNF-a to induce COX-2 expression as well as several other inflammatory factors in primary colon epithelial cells.   Interestingly, oxLDL enhanced TGF-β expression only in ApoE

©2016 The Author(s).

Keywords: ApoE; colon; inflammation; nuclear factor kappaB; tumour necrosis factors

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