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Beisel T, Diehl AM, Manolikakes G. Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Arylglycines. Org Lett. 2016;18(16):4116-9doi: 10.1021/acs.orglett.6b02045.
Beisel, T., Diehl, A. M., & Manolikakes, G. (2016). Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Arylglycines. Organic letters, 18(16), 4116-9. https://doi.org/10.1021/acs.orglett.6b02045
Beisel, Tamara, et al. "Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Arylglycines." Organic letters vol. 18,16 (2016): 4116-9. doi: https://doi.org/10.1021/acs.orglett.6b02045
Beisel T, Diehl AM, Manolikakes G. Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Arylglycines. Org Lett. 2016 Aug 19;18(16):4116-9. doi: 10.1021/acs.orglett.6b02045. Epub 2016 Aug 09. PMID: 27505131.
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Org Lett. 2016 Aug 19;18(16):4116-9. doi: 10.1021/acs.orglett.6b02045. Epub 2016 Aug 09.

Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Arylglycines.

Organic letters

Tamara Beisel, Andreas M Diehl, Georg Manolikakes

Affiliations

  1. Department of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt am Main , Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.

PMID: 27505131 DOI: 10.1021/acs.orglett.6b02045

Abstract

A general Pd-catalyzed, enantioselective three-component synthesis of α-arylglycines starting from sulfonamides, glyoxylic acid derivatives, and boronic acids was developed. This operationally straightforward procedure enables the preparation of a wide variety of α-arylglycines in high yields and excellent levels of enantioselectivity from a simple set of readily available starting materials. Incorporation of Pbf-amides gives a racemization-free access to N-unprotected α-arylglycines.

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