Display options
Cite
Isoo N, Ohno T, Isowaki M, et al. The decline in synaptic GluN2B and rise in inhibitory neurotransmission determine the end of a critical period. Sci Rep. 2016;6:34196doi: 10.1038/srep34196.
Isoo, N., Ohno, T., Isowaki, M., Fukuda, S., Murabe, N., Mizukami, H., Ozawa, K., Mishina, M., & Sakurai, M. (2016). The decline in synaptic GluN2B and rise in inhibitory neurotransmission determine the end of a critical period. Scientific reports, 634196. https://doi.org/10.1038/srep34196
Isoo, Noriko, et al. "The decline in synaptic GluN2B and rise in inhibitory neurotransmission determine the end of a critical period." Scientific reports vol. 6 (2016): 34196. doi: https://doi.org/10.1038/srep34196
Isoo N, Ohno T, Isowaki M, Fukuda S, Murabe N, Mizukami H, Ozawa K, Mishina M, Sakurai M. The decline in synaptic GluN2B and rise in inhibitory neurotransmission determine the end of a critical period. Sci Rep. 2016 Sep 28;6:34196. doi: 10.1038/srep34196. PMID: 27677249; PMCID: PMC5039748.
Copy Download .nbib Format: NLM
Share it on

Sci Rep. 2016 Sep 28;6:34196. doi: 10.1038/srep34196.

The decline in synaptic GluN2B and rise in inhibitory neurotransmission determine the end of a critical period.

Scientific reports

Noriko Isoo, Takae Ohno, Mutsumi Isowaki, Satoshi Fukuda, Naoyuki Murabe, Hiroaki Mizukami, Keiya Ozawa, Masayoshi Mishina, Masaki Sakurai

Affiliations

  1. Department of Physiology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
  2. Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimono, Tochigi 329-0498, Japan.
  3. Division of Genetic Therapeutics, the Institute of Medical Science, the University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
  4. Department of Molecular Neurobiology &Pharmacology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
  5. Brain Science Laboratory, The Research Organization of Science and Technology, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan.

PMID: 27677249 PMCID: PMC5039748 DOI: 10.1038/srep34196

Abstract

Neuronal plasticity is especially active in the young, during short windows of time termed critical periods, and loss of a critical period leads to functional limitations in the adults. The mechanism that governs the length of critical periods remains unknown. Here we show that levels of the NMDA receptor GluN2B subunit, which functions as a Ca

References

  1. Brain Res. 1988 Jan 1;466(1):103-19 - PubMed
  2. J Neurosci. 2015 Jan 21;35(3):1181-91 - PubMed
  3. Neuron. 2007 Sep 6;55(5):779-85 - PubMed
  4. Science. 1998 Nov 20;282(5393):1504-8 - PubMed
  5. Neuroscience. 2005;132(4):917-22 - PubMed
  6. Prog Neurobiol. 2009 Sep;89(1):46-60 - PubMed
  7. Nature. 2000 Mar 9;404(6774):183-6 - PubMed
  8. J Neurosci. 1992 May;12(5):1826-38 - PubMed
  9. Neuroscientist. 2013 Feb;19(1):62-75 - PubMed
  10. Neuron. 2010 Sep 23;67(6):984-96 - PubMed
  11. J Biol Chem. 2007 Apr 27;282(17):12388-96 - PubMed
  12. Nature. 1994 Mar 10;368(6467):144-7 - PubMed
  13. Nat Neurosci. 2005 Aug;8(8):1069-77 - PubMed
  14. J Neurosci. 1997 Apr 1;17(7):2469-76 - PubMed
  15. Neuron. 2001 Nov 20;32(4):619-34 - PubMed
  16. Annu Rev Neurosci. 2004;27:549-79 - PubMed
  17. Vision Res. 1994 Mar;34(6):709-20 - PubMed
  18. Eur J Neurosci. 2012 May;35(10):1540-53 - PubMed
  19. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2854-9 - PubMed
  20. Neurosci Res. 1995 Nov;23(4):377-82 - PubMed
  21. J Neurophysiol. 2006 Apr;95(4):2304-13 - PubMed
  22. J Neurochem. 2015 Jan;132(1):110-23 - PubMed
  23. Neuron. 2003 Nov 13;40(4):775-84 - PubMed
  24. Nat Neurosci. 2001 Mar;4(3):235-6 - PubMed
  25. J Neurosci. 1997 Aug 15;17(16):6264-76 - PubMed
  26. J Physiol. 1970 Feb;206(2):419-36 - PubMed
  27. J Neurosci. 2005 Feb 23;25(8):2010-23 - PubMed
  28. Neuron. 2005 Jun 2;46(5):745-60 - PubMed
  29. Neuron. 2005 Oct 20;48(2):289-301 - PubMed
  30. Neuroscience. 2007 Dec 19;150(4):829-40 - PubMed
  31. J Neurophysiol. 1996 Aug;76(2):984-94 - PubMed
  32. Brain Res Dev Brain Res. 1994 Apr 15;78(2):182-90 - PubMed
  33. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15252-7 - PubMed
  34. J Neurosci. 2003 Jun 15;23(12):5208-18 - PubMed
  35. Neuroscience. 2002;109(2):359-70 - PubMed
  36. Neuron. 1996 Feb;16(2):333-44 - PubMed
  37. J Neurosci. 2004 Feb 11;24(6):1377-84 - PubMed
  38. J Comp Neurol. 2009 Mar 10;513(2):164-72 - PubMed
  39. Biochem Biophys Res Commun. 2012 Jul 13;423(4):661-6 - PubMed
  40. J Comp Neurol. 2006 Feb 10;494(5):738-51 - PubMed
  41. J Neurosci. 2004 Oct 6;24(40):8885-95 - PubMed
  42. J Neurosci. 2003 Jul 23;23(16):6557-66 - PubMed
  43. Nature. 1995 May 25;375(6529):325-8 - PubMed

Publication Types