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Keung W, Ren L, Sen Li, et al. Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial K. Sci Rep. 2016;6:34154doi: 10.1038/srep34154.
Keung, W., Ren, L., Sen Li, Wong, A. O., Chopra, A., Kong, C. W., Tomaselli, G. F., Chen, C. S., & Li, R. A. (2016). Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial K. Scientific reports, 634154. https://doi.org/10.1038/srep34154
Keung, Wendy, et al. "Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial K." Scientific reports vol. 6 (2016): 34154. doi: https://doi.org/10.1038/srep34154
Keung W, Ren L, Sen Li, Wong AO, Chopra A, Kong CW, Tomaselli GF, Chen CS, Li RA. Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial K. Sci Rep. 2016 Sep 28;6:34154. doi: 10.1038/srep34154. PMID: 27677332; PMCID: PMC5039730.
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Sci Rep. 2016 Sep 28;6:34154. doi: 10.1038/srep34154.

Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial K.

Scientific reports

Wendy Keung, Lihuan Ren, Sen Li, Andy On-Tik Wong, Anant Chopra, Chi-Wing Kong, Gordon F Tomaselli, Christopher S Chen, Ronald A Li

Affiliations

  1. Stem Cell &Regenerative Medicine Consortium, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.
  2. Department of Physiology, The University of Hong Kong, Hong Kong.
  3. Department of Bioengineering, Boston University, Boston, MA, USA.
  4. Harvard Wyss Institute for Biologically Inspired Engineering, Boston, MA, USA.
  5. Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, M.D., United States of America.
  6. Dr. Li Dak-Sum Research Centre, The University of Hong Kong - Karolinska Institutet Collaborations in Regenerative Medicine, The University of Hong Kong, Hong Kong.
  7. Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Sweden.

PMID: 27677332 PMCID: PMC5039730 DOI: 10.1038/srep34154

Abstract

Human embryonic stem cells (hESCs) is a potential unlimited ex vivo source of ventricular (V) cardiomyocytes (CMs), but hESC-VCMs and their engineered tissues display immature traits. In adult VCMs, sarcolemmal (sarc) and mitochondrial (mito) ATP-sensitive potassium (K

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