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Holland AM, Roberts MD, Mumford PW, et al. Testosterone inhibits expression of lipogenic genes in visceral fat by an estrogen-dependent mechanism. J Appl Physiol (1985). 2016;121(3):792-805doi: 10.1152/japplphysiol.00238.2016.
Holland, A. M., Roberts, M. D., Mumford, P. W., Mobley, C. B., Kephart, W. C., Conover, C. F., Beggs, L. A., Balaez, A., Otzel, D. M., Yarrow, J. F., Borst, S. E., & Beck, D. T. (2016). Testosterone inhibits expression of lipogenic genes in visceral fat by an estrogen-dependent mechanism. Journal of applied physiology (Bethesda, Md. : 1985), 121(3), 792-805. https://doi.org/10.1152/japplphysiol.00238.2016
Holland, A Maleah, et al. "Testosterone inhibits expression of lipogenic genes in visceral fat by an estrogen-dependent mechanism." Journal of applied physiology (Bethesda, Md. : 1985) vol. 121,3 (2016): 792-805. doi: https://doi.org/10.1152/japplphysiol.00238.2016
Holland AM, Roberts MD, Mumford PW, Mobley CB, Kephart WC, Conover CF, Beggs LA, Balaez A, Otzel DM, Yarrow JF, Borst SE, Beck DT. Testosterone inhibits expression of lipogenic genes in visceral fat by an estrogen-dependent mechanism. J Appl Physiol (1985). 2016 Sep 01;121(3):792-805. doi: 10.1152/japplphysiol.00238.2016. Epub 2016 Aug 18. PMID: 27539493.
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J Appl Physiol (1985). 2016 Sep 01;121(3):792-805. doi: 10.1152/japplphysiol.00238.2016. Epub 2016 Aug 18.

Testosterone inhibits expression of lipogenic genes in visceral fat by an estrogen-dependent mechanism.

Journal of applied physiology (Bethesda, Md. : 1985)

A Maleah Holland, Michael D Roberts, Petey W Mumford, C Brooks Mobley, Wesley C Kephart, Christine F Conover, Luke A Beggs, Alexander Balaez, Dana M Otzel, Joshua F Yarrow, Stephen E Borst, Darren T Beck

Affiliations

  1. School of Kinesiology, Auburn University, Auburn, Alabama;
  2. School of Kinesiology, Auburn University, Auburn, Alabama; Department of Cell Biology and Physiology, Edward Via College of Osteopathic Medicine-Auburn Campus, Auburn, Alabama.
  3. Malcom Randall Veterans Affairs Medical Center, Geriatric Research Education and Clinical Center, Gainesville, Florida;
  4. Malcom Randall Veterans Affairs Medical Center, Geriatric Research Education and Clinical Center, Gainesville, Florida; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida; and.
  5. School of Kinesiology, Auburn University, Auburn, Alabama; Department of Cell Biology and Physiology, Edward Via College of Osteopathic Medicine-Auburn Campus, Auburn, Alabama [email protected].

PMID: 27539493 DOI: 10.1152/japplphysiol.00238.2016

Abstract

The influence of the aromatase enzyme on the chronic fat-sparing effects of testosterone requires further elucidation. Our purpose was to determine whether chronic anastrozole (AN, an aromatase inhibitor) treatment alters testosterone-mediated lipolytic/lipogenic gene expression in visceral fat. Ten-month-old Fischer 344 rats (n = 6/group) were subjected to sham surgery (SHAM), orchiectomy (ORX), ORX + treatment with testosterone enanthate (TEST, 7.0 mg/wk), or ORX + TEST + AN (0.5 mg/day), with drug treatment beginning 14 days postsurgery. At day 42, ORX animals exhibited nearly undetectable serum testosterone and 29% higher retroperitoneal fat mass than SHAM animals (P < 0.001). TEST produced a ∼380-415% higher serum testosterone than SHAM (P < 0.001) and completely prevented ORX-induced visceral fat gain (P < 0.001). Retroperitoneal fat was 21% and 16% lower in ORX + TEST than SHAM (P < 0.001) and ORX + TEST + AN (P = 0.007) animals, while serum estradiol (E

Keywords: adipose; androgen; aromatase; estrogen; steroids

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