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van Ingen G, Li J, Goedegebure A, et al. Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene. Nat Commun. 2016;7:12792doi: 10.1038/ncomms12792.
van Ingen, G., Li, J., Goedegebure, A., Pandey, R., Li, Y. R., March, M. E., Jaddoe, V. W., Bakay, M., Mentch, F. D., Thomas, K., Wei, Z., Chang, X., Hain, H. S., Uitterlinden, A. G., Moll, H. A., van Duijn, C. M., Rivadeneira, F., Raat, H., Baatenburg de Jong, R. J., Sleiman, P. M., van der Schroeff, M. P., & Hakonarson, H. (2016). Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene. Nature communications, 712792. https://doi.org/10.1038/ncomms12792
van Ingen, Gijs, et al. "Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene." Nature communications vol. 7 (2016): 12792. doi: https://doi.org/10.1038/ncomms12792
van Ingen G, Li J, Goedegebure A, Pandey R, Li YR, March ME, Jaddoe VW, Bakay M, Mentch FD, Thomas K, Wei Z, Chang X, Hain HS, Uitterlinden AG, Moll HA, van Duijn CM, Rivadeneira F, Raat H, Baatenburg de Jong RJ, Sleiman PM, van der Schroeff MP, Hakonarson H. Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene. Nat Commun. 2016 Sep 28;7:12792. doi: 10.1038/ncomms12792. PMID: 27677580; PMCID: PMC5052699.
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Nat Commun. 2016 Sep 28;7:12792. doi: 10.1038/ncomms12792.

Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene.

Nature communications

Gijs van Ingen, Jin Li, André Goedegebure, Rahul Pandey, Yun Rose Li, Michael E March, Vincent W V Jaddoe, Marina Bakay, Frank D Mentch, Kelly Thomas, Zhi Wei, Xiao Chang, Heather S Hain, André G Uitterlinden, Henriette A Moll, Cornelia M van Duijn, Fernando Rivadeneira, Hein Raat, Robert J Baatenburg de Jong, Patrick M Sleiman, Marc P van der Schroeff, Hakon Hakonarson

Affiliations

  1. Department of Otolaryngology, Head and Neck Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, The Netherlands.
  2. The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, The Netherlands.
  3. Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  4. Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, The Netherlands.
  5. Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, The Netherlands.
  6. Department of Computer Science, New Jersey Institute of Technology, Newark 07102, New Jersey, USA.
  7. Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, The Netherlands.
  8. Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, The Netherlands.
  9. Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  10. Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

PMID: 27677580 PMCID: PMC5052699 DOI: 10.1038/ncomms12792

Abstract

Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent reason for antibiotic treatment in children. Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (rs2932989, P

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