Display options
Cite
Hori T, Onishi Y, Kamei H, et al. Fibrosing cholestatic hepatitis C in post-transplant adult recipients of liver transplantation. Ann Gastroenterol. 2016;29(4):454-459doi: 10.20524/aog.2016.0069.
Hori, T., Onishi, Y., Kamei, H., Kurata, N., Ishigami, M., Ishizu, Y., & Ogura, Y. (2016). Fibrosing cholestatic hepatitis C in post-transplant adult recipients of liver transplantation. Annals of gastroenterology, 29(4), 454-459. https://doi.org/10.20524/aog.2016.0069
Hori, Tomohide, et al. "Fibrosing cholestatic hepatitis C in post-transplant adult recipients of liver transplantation." Annals of gastroenterology vol. 29,4 (2016): 454-459. doi: https://doi.org/10.20524/aog.2016.0069
Hori T, Onishi Y, Kamei H, Kurata N, Ishigami M, Ishizu Y, Ogura Y. Fibrosing cholestatic hepatitis C in post-transplant adult recipients of liver transplantation. Ann Gastroenterol. 2016 Oct-Dec;29(4):454-459. doi: 10.20524/aog.2016.0069. Epub 2016 Jul 08. PMID: 27708510; PMCID: PMC5049551.
Copy Download .nbib Format: NLM
Share it on

Ann Gastroenterol. 2016 Oct-Dec;29(4):454-459. doi: 10.20524/aog.2016.0069. Epub 2016 Jul 08.

Fibrosing cholestatic hepatitis C in post-transplant adult recipients of liver transplantation.

Annals of gastroenterology

Tomohide Hori, Yasuharu Onishi, Hideya Kamei, Nobuhiko Kurata, Masatoshi Ishigami, Yoji Ishizu, Yasuhiro Ogura

Affiliations

  1. Department of Transplant Surgery (Tohomide Hori, Yasuharu Onishi, Hideya Kamei, Nobuhiko Kurata, Yasuhiro Ogura), Nagoya University Hospital, Nagoya, Japan.
  2. Department of Gastroenterology and Hepatology (Masatoshi Ishigami), Nagoya University Hospital, Nagoya, Japan.

PMID: 27708510 PMCID: PMC5049551 DOI: 10.20524/aog.2016.0069

Abstract

Hepatitis C recurrence continues to present a major challenge in liver transplantation (LT). Approximately 10% of hepatitis C virus (HCV)-positive recipients will develop fibrosing cholestatic hepatitis (FCH) after LT. FCH is clinically characterized as marked jaundice with cholestatic hepatic dysfunction and high titers of viremia. Pathologically, FCH manifests as marked hepatocyte swelling, cholestasis, periportal peritrabecular fibrosis and only mild inflammation. This progressive form usually involves acute liver failure, and rapidly results in graft loss. A real-time and precise diagnosis based on histopathological examination and viral measurement is indispensable for the adequate treatment of FCH. Typical pathological findings of FCH are shown. Currently, carefully selected combinations of direct-acting antivirals (DAAs) offer the potential for highly effective and safe regimens for hepatitis C, both in the pre- and post-transplant settings. Here, we review FCH caused by HCV in LT recipients, and current strategies for sustained virological responses after LT. Only a few cases of successfully treated FCH C after LT by DAAs have been reported. The diagnostic findings and therapeutic dilemma are discussed based on a literature review.

Keywords: Fibrosing cholestatic hepatitis; hepatitis C; intractable ascites; liver transplantation; portal hypertension

Conflict of interest statement

None

References

  1. Hepatology. 2006 Mar;43(3):492-9 - PubMed
  2. Curr Opin Organ Transplant. 2010 Jun;15(3):301-9 - PubMed
  3. J Hepatol. 2007 Mar;46(3):459-65 - PubMed
  4. Curr Opin Gastroenterol. 2016 May;32(3):152-8 - PubMed
  5. N Engl J Med. 1996 Mar 28;334(13):815-20 - PubMed
  6. Clin Transplant. 2012 May-Jun;26(3):E324-34 - PubMed
  7. Am J Transplant. 2005 Jan;5(1):118-24 - PubMed
  8. J Clin Transl Hepatol. 2015 Jun 28;3(2):140-8 - PubMed
  9. Hepatology. 2015 May;61(5):1485-94 - PubMed
  10. Liver Int. 2015 Feb;35(2):381-90 - PubMed
  11. World J Gastroenterol. 2014 Nov 28;20(44):16409-17 - PubMed
  12. Am J Transplant. 2006 Jul;6(7):1578-85 - PubMed
  13. Hepatology. 2002 Jul;36(1):202-10 - PubMed
  14. J Hepatol. 2000 Apr;32(4):673-84 - PubMed
  15. Int J Clin Exp Pathol. 2008 Jan 01;1(5):396-402 - PubMed
  16. Hepatology. 1991 Jan;13(1):150-7 - PubMed
  17. World J Gastroenterol. 2015 Aug 28;21(32):9526-33 - PubMed
  18. Liver Transpl. 2003 Nov;9(11):S28-34 - PubMed
  19. PLoS One. 2015 Aug 27;10(8):e0135645 - PubMed
  20. J Hepatol. 2007 Dec;47(6):793-8 - PubMed
  21. Ann Hepatol. 2013 Jan-Feb;12 (1):156-60 - PubMed
  22. Transpl Infect Dis. 2016 Jun;18(3):326-32 - PubMed
  23. Gastroenterology. 2007 May;132(5):1746-56 - PubMed
  24. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD006803 - PubMed
  25. Am J Transplant. 2008 Nov;8(11):2426-33 - PubMed
  26. Hepatology. 2010 Jan;51(1):23-34 - PubMed
  27. Transplantation. 2011 Dec 15;92(11):1259-68 - PubMed
  28. Aliment Pharmacol Ther. 2005 Dec;22(11-12):1079-89 - PubMed
  29. Eur J Gastroenterol Hepatol. 2011 Nov;23(12):1178-84 - PubMed
  30. Hepatology. 2005 Feb;41(2):289-98 - PubMed
  31. J Hepatol. 2008 Aug;49(2):274-87 - PubMed
  32. Transplantation. 2016 May;100(5):1059-65 - PubMed
  33. Liver Transpl. 2005 May;11(5):479-89 - PubMed
  34. Hepatology. 2016 May;63(5):1493-505 - PubMed
  35. J Hepatol. 1992 Jan;14(1):104-11 - PubMed
  36. PLoS One. 2015 Jun 17;10(6):e0128774 - PubMed
  37. Liver Transpl. 2006 May;12(5):762-7 - PubMed
  38. Am J Pathol. 1992 Jun;140(6):1295-308 - PubMed
  39. PLoS One. 2014 Sep 08;9(9):e107057 - PubMed
  40. Clin Transplant. 2012 Nov-Dec;26(6):857-67 - PubMed
  41. Transpl Int. 2015 Feb;28(2):255-8 - PubMed
  42. Liver Transpl. 2012 Jun;18(6):671-9 - PubMed
  43. Liver Transpl. 2010 Jun;16(6):718-28 - PubMed
  44. Transplantation. 2004 Jan 27;77(2):226-31 - PubMed
  45. Liver Transpl. 2003 Nov;9(11):1152-8 - PubMed
  46. Hepatology. 2002 Mar;35(3):680-7 - PubMed
  47. Hepatology. 1994 Jul;20(1 Pt 1):15-20 - PubMed
  48. Clin Gastroenterol Hepatol. 2015 Nov;13(11):1993-2001.e1-2 - PubMed
  49. Am J Pathol. 1990 Sep;137(3):667-76 - PubMed
  50. Hepatology. 1991 Apr;13(4):619-26 - PubMed
  51. Liver Transpl. 2001 Sep;7(9):790-6 - PubMed
  52. Clin Transplant. 2015 Sep;29(9):813-9 - PubMed
  53. Hepatology. 2000 Aug;32(2):418-26 - PubMed
  54. J Hepatol. 2006 Apr;44(4):717-22 - PubMed
  55. Nat Rev Gastroenterol Hepatol. 2015 May;12(5):284-92 - PubMed
  56. Am J Transplant. 2008 Mar;8(3):679-87 - PubMed
  57. Curr Opin Infect Dis. 2015 Oct;28(5):471-8 - PubMed
  58. Hepatology. 2002 Oct;36(4 Pt 1):973-7 - PubMed
  59. Liver Transpl. 2003 Nov;9(11):S1-9 - PubMed
  60. Gastroenterology. 1992 Oct;103(4):1307-12 - PubMed

Publication Types