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Asakura H, Takahashi H, Uchiyama T, et al. Proposal for new diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis. Thromb J. 2016;14:42doi: 10.1186/s12959-016-0117-x.
Asakura, H., Takahashi, H., Uchiyama, T., Eguchi, Y., Okamoto, K., Kawasugi, K., Madoiwa, S., Wada, H. (2016). Proposal for new diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis. Thrombosis journal, 1442. https://doi.org/10.1186/s12959-016-0117-x
Asakura, Hidesaku, et al. "Proposal for new diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis." Thrombosis journal vol. 14 (2016): 42. doi: https://doi.org/10.1186/s12959-016-0117-x
Asakura H, Takahashi H, Uchiyama T, Eguchi Y, Okamoto K, Kawasugi K, Madoiwa S, Wada H. Proposal for new diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis. Thromb J. 2016 Sep 28;14:42. doi: 10.1186/s12959-016-0117-x. eCollection 2016. PMID: 27708553; PMCID: PMC5039801.
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Thromb J. 2016 Sep 28;14:42. doi: 10.1186/s12959-016-0117-x. eCollection 2016.

Proposal for new diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis.

Thrombosis journal

Hidesaku Asakura, Hoyu Takahashi, Toshimasa Uchiyama, Yutaka Eguchi, Kohji Okamoto, Kazuo Kawasugi, Seiji Madoiwa, Hideo Wada,

Affiliations

  1. Department of Internal Medicine (III), Kanazawa University School of Medicine, 13-1, Takaramachi, Kanazawa, 920-8641 Japan.
  2. Department of Internal Medicine, Niigata Prefectural Kamo Hospital, 1-9-1 Aomicho, Kamo, Niigata 959-1397 Japan.
  3. Department of Laboratory Medicine, National Hospital Organization Takasaki General Medical Center, 36 Takamatsu-Cho, Takasaki, Gunma 370-0829 Japan.
  4. Department of Critical and Intensive Care Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192 Japan.
  5. Gastroenterology and Hepatology Center, Kitakyushu City Yahata Hospital, 4-18-1, Nishihon-machi, Yahatahigashi-ku, Kitakyushu, Fukuoka 805-8534 Japan.
  6. Department of Hematology, Teikyo University School of Medicine, 2-11-1 Kaga Itabashi-Ku, Tokyo, 173-8605 Japan.
  7. Department of Clinical and Laboratory Medicine, Tokyo Saiseikai Central Hospital, 1-4-17, Mita, Minato-ku, Tokyo, 108-0073 Japan.
  8. Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507 Japan.

PMID: 27708553 PMCID: PMC5039801 DOI: 10.1186/s12959-016-0117-x

Abstract

Disseminated intravascular coagulation (DIC) is a serious disease that, in the presence of underlying disease, causes persistent, generalized, marked coagulation activation. Early treatment based on an appropriate diagnosis is very important for improving patients' prognosis, to which end diagnostic criteria play a key role. Several criteria have been proposed, but each has its strengths and weaknesses, and improved criteria are needed. Widespread use of coagulofibrinolytic markers has elucidated that the pathology of DIC differs greatly as a function of the underlying disease. Thus, discriminating use of DIC diagnostic criteria that take underlying diseases into account is important. DIC diagnostic criteria that are well known in Japan include the Japanese Ministry of Health and Welfare's old DIC diagnostic criteria (JMHW criteria), the International Society on Thrombosis and Haemostasis's DIC diagnostic criteria (ISTH criteria), and the Japanese Association for Acute Medicine's acute-stage DIC diagnostic criteria (JAAM criteria). Those criteria have their respective drawbacks: the sensitivity of the ISTH criteria is poor, the JAAM criteria cannot be applied to all underlying diseases, and the JMHW criteria have poor sensitivity in the case of infections, do not use molecular markers, and result in misdiagnosis. The Japanese Society on Thrombosis and Hemostasis's newly proposed provisional draft DIC diagnostic criteria (new criteria) use diagnostic criteria classifications of "hematopoietic disorder type", "infectious type", and "basic type" based on the underlying pathology. For the hematopoietic disorder type the platelet count is omitted from the score, while for the infectious type, fibrinogen is omitted from the score. Also, points are added if the platelet count decreases with time. In the new criteria, molecular markers and antithrombin activity have been newly included, and as a countermeasure for misdiagnosis, 3 points are deducted if there is liver failure. In this paper, we discuss various problems encountered with DIC diagnosis, and we describe the new criteria together with the events that led to their creation. These new diagnostic criteria take into account the underlying diseases of wide area, and we expect that they will serve clinicians well due to the above adaptations and improvements.

Keywords: DIC; Diagnostic criteria; Disseminated intravascular coagulation; Enhanced-fibrinolytic-type DIC; Suppressed-fibrinolytic-type DIC

References

  1. Clin Appl Thromb Hemost. 2010 Dec;16(6):688-93 - PubMed
  2. N Engl J Med. 1999 Apr 1;340(13):994-1004 - PubMed
  3. Am J Hematol. 1992 Dec;41(4):303-4 - PubMed
  4. Am J Hematol. 2006 Dec;81(12):907-14 - PubMed
  5. Blood. 1984 Apr;63(4):965-9 - PubMed
  6. Shock. 2013 Jun;39(6):514-9 - PubMed
  7. Thromb Res. 2012 Sep;130(3):e129-33 - PubMed
  8. Thromb Res. 2010 Jul;126(1):74-8 - PubMed
  9. Crit Care. 2014 Jan 20;18(1):R19 - PubMed
  10. Eur J Haematol. 2001 Sep;67(3):170-5 - PubMed
  11. Thromb Haemost. 2009 Apr;101(4):696-705 - PubMed
  12. Crit Care Clin. 2012 Jul;28(3):373-88, vi - PubMed
  13. Thromb Res. 2013 Sep;132(3):386-91 - PubMed
  14. J Hepatol. 2009 Aug;51(2):288-95 - PubMed
  15. Intensive Care Med. 2005 Sep;31(9):1209-14 - PubMed
  16. Thromb Haemost. 2001 Nov;86(5):1327-30 - PubMed
  17. Shock. 2007 Feb;27(2):139-44 - PubMed
  18. J Thromb Haemost. 2013 Feb 4;:null - PubMed
  19. Ann Thorac Surg. 2009 Oct;88(4):1331-3 - PubMed
  20. J Crit Care. 2013 Oct;28(5):556-63 - PubMed
  21. Crit Care Med. 1995 Nov;23(11):1835-42 - PubMed
  22. Int J Hematol. 2008 May;87(4):371-4 - PubMed
  23. Thromb Haemost. 2008 Dec;100(6):1099-105 - PubMed
  24. Blood. 2000 Mar 1;95(5):1721-8 - PubMed
  25. J Thromb Haemost. 2006 Jan;4(1):90-7 - PubMed
  26. Thromb Res. 2012 Apr;129(4):e119-25 - PubMed
  27. Surgery. 2011 Feb;149(2):221-30 - PubMed
  28. Crit Care Med. 2005 Feb;33(2):341-8 - PubMed
  29. Crit Care Med. 1998 Jan;26(1):149-56 - PubMed
  30. Thromb J. 2006 Feb 21;4:4 - PubMed
  31. J Obstet Gynaecol Can. 2012 Apr;34(4):341-7 - PubMed
  32. N Engl J Med. 2003 Sep 25;349(13):1227-35 - PubMed
  33. Clin Lab Haematol. 1994 Mar;16(1):9-13 - PubMed
  34. J Thromb Haemost. 2004 Nov;2(11):1924-33 - PubMed
  35. Thromb Res. 2012 Mar;129(3):290-5 - PubMed
  36. N Engl J Med. 2014 Feb 27;370(9):847-59 - PubMed
  37. N Engl J Med. 1999 Aug 19;341(8):586-92 - PubMed
  38. Hepatol Res. 2011 Sep;41(9):805-12 - PubMed
  39. Pancreas. 2006 Jan;32(1):87-92 - PubMed
  40. Thromb Res. 1992 Oct 1;68(1):57-65 - PubMed
  41. Thromb Haemost. 2006 Feb;95(2):282-7 - PubMed
  42. Am J Hematol. 2004 Jul;76(3):225-9 - PubMed
  43. World J Gastroenterol. 2008 Mar 14;14(10):1549-52 - PubMed
  44. J Thromb Haemost. 2006 Jun;4(6):1253-8 - PubMed
  45. Thromb Haemost. 1990 Jun 28;63(3):340-4 - PubMed
  46. Crit Care Med. 2006 Mar;34(3):625-31 - PubMed
  47. Blood. 1996 Aug 1;88(3):881-6 - PubMed
  48. Thromb Res. 2013 Oct;132(4):457-64 - PubMed
  49. Clin Appl Thromb Hemost. 2001 Jul;7(3):229-33 - PubMed
  50. Thromb Haemost. 1995 Sep;74(3):848-52 - PubMed
  51. Lancet. 1999 Jan 16;353(9148):190-5 - PubMed
  52. Blood. 2006 Jan 15;107(2):528-34 - PubMed
  53. Intensive Care Med. 2008 Apr;34(4):700-6 - PubMed
  54. Br J Haematol. 2009 Apr;145(1):24-33 - PubMed
  55. Blood Coagul Fibrinolysis. 2003 Apr;14(3):221-8 - PubMed
  56. Crit Care Med. 2005 Oct;33(10):2214-21 - PubMed
  57. Am J Hematol. 2003 Sep;74(1):17-22 - PubMed
  58. Thromb Res. 2011 Apr;127(4):349-55 - PubMed
  59. Circ J. 2005 Sep;69(9):1150-3 - PubMed
  60. Br J Surg. 1973 Aug;60(8):646-9 - PubMed
  61. Clin Appl Thromb Hemost. 2012 Nov;18(6):628-32 - PubMed
  62. Chest. 1992 Mar;101(3):816-23 - PubMed
  63. Crit Care Med. 2008 Jan;36(1):145-50 - PubMed
  64. J Intensive Care. 2014 Mar 06;2(1):20 - PubMed
  65. Blood Coagul Fibrinolysis. 1994 Oct;5(5):829-32 - PubMed
  66. Thromb Res. 2007;121(1):67-73 - PubMed
  67. Thromb Res. 2012 May;129(5):e177-84 - PubMed
  68. Thromb Res. 2011 Aug;128(2):186-90 - PubMed
  69. J Thromb Haemost. 2013 May;11(5):826-35 - PubMed
  70. Crit Care Med. 2010 Feb;38(2 Suppl):S35-42 - PubMed
  71. Thromb Res. 2008;123(2):390-5 - PubMed
  72. Am J Hematol. 1999 Apr;60(4):273-8 - PubMed
  73. Ann Lab Med. 2014 Mar;34(2):85-91 - PubMed
  74. Crit Care Med. 2001 Jun;29(6):1164-8 - PubMed
  75. Am J Hematol. 2006 Mar;81(3):171-4 - PubMed
  76. Pol J Pharmacol. 1996 Jan-Feb;48(1):73-5 - PubMed
  77. Hepatology. 2007 Aug;46(2):520-7 - PubMed
  78. Oncology. 2011;81(2):119-25 - PubMed
  79. Thromb Haemost. 2005 Nov;94(5):975-9 - PubMed
  80. Thromb Haemost. 1996 Feb;75(2):224-8 - PubMed
  81. Int J Hematol. 2007 Dec;86(5):403-6 - PubMed
  82. Haemostasis. 1992;22(1):17-24 - PubMed
  83. Thromb Res. 2007;119(2):229-40 - PubMed
  84. Am J Hematol. 1990 Feb;33(2):90-5 - PubMed
  85. Thromb Res. 2010 Jan;125(1):6-11 - PubMed
  86. Crit Care Med. 2000 Jun;28(6):1777-80 - PubMed
  87. Clin Appl Thromb Hemost. 2005 Oct;11(4):391-400 - PubMed
  88. Semin Thromb Hemost. 2016 Mar;42(2):155-65 - PubMed
  89. Thromb Haemost. 2004 Apr;91(4):812-8 - PubMed
  90. Thromb Res. 2009 Nov;124(5):608-13 - PubMed
  91. Int J Hematol. 2006 Dec;84(5):398-405 - PubMed
  92. Thromb Haemost. 2004 Nov;92(5):997-1002 - PubMed
  93. Crit Care Med. 2004 Dec;32(12):2416-21 - PubMed
  94. Blood Res. 2013 Dec;48(4):250-3 - PubMed
  95. Bibl Haematol. 1983;(49):265-75 - PubMed
  96. Crit Care. 2006;10(4):222 - PubMed
  97. Blood Coagul Fibrinolysis. 2006 Sep;17(6):445-51 - PubMed
  98. Thromb Haemost. 2011 Jan;105(1):40-4 - PubMed

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