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Alexander J, Potamianou H, Xing J, et al. Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology. Front Neurosci. 2016;10:428doi: 10.3389/fnins.2016.00428.
Alexander, J., Potamianou, H., Xing, J., Deng, L., Karagiannidis, I., Tsetsos, F., Drineas, P., Tarnok, Z., Rizzo, R., Wolanczyk, T., Farkas, L., Nagy, P., Szymanska, U., Androutsos, C., Tsironi, V., Koumoula, A., Barta, C., Sandor, P., Barr, C. L., Tischfield, J., Paschou, P., Heiman, G. A., & Georgitsi, M. (2016). Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology. Frontiers in neuroscience, 10428. https://doi.org/10.3389/fnins.2016.00428
Alexander, John, et al. "Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology." Frontiers in neuroscience vol. 10 (2016): 428. doi: https://doi.org/10.3389/fnins.2016.00428
Alexander J, Potamianou H, Xing J, Deng L, Karagiannidis I, Tsetsos F, Drineas P, Tarnok Z, Rizzo R, Wolanczyk T, Farkas L, Nagy P, Szymanska U, Androutsos C, Tsironi V, Koumoula A, Barta C, Sandor P, Barr CL, Tischfield J, Paschou P, Heiman GA, Georgitsi M. Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology. Front Neurosci. 2016 Sep 21;10:428. doi: 10.3389/fnins.2016.00428. eCollection 2016. PMID: 27708560; PMCID: PMC5030307.
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Front Neurosci. 2016 Sep 21;10:428. doi: 10.3389/fnins.2016.00428. eCollection 2016.

Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology.

Frontiers in neuroscience

John Alexander, Hera Potamianou, Jinchuan Xing, Li Deng, Iordanis Karagiannidis, Fotis Tsetsos, Petros Drineas, Zsanett Tarnok, Renata Rizzo, Tomasz Wolanczyk, Luca Farkas, Peter Nagy, Urszula Szymanska, Christos Androutsos, Vaia Tsironi, Anastasia Koumoula, Csaba Barta, Paul Sandor, Cathy L Barr, Jay Tischfield, Peristera Paschou, Gary A Heiman, Marianthi Georgitsi

Affiliations

  1. Department of Molecular Biology and Genetics, Democritus University of Thrace Alexandroupoli, Greece.
  2. Department of Genetics, Rutgers, The State University of New JerseyPiscataway, NJ, USA; Human Genetics Institute of New Jersey, Rutgers, The State University of New JerseyPiscataway, NJ, USA.
  3. Computer Science Department, Purdue University West Lafayette, USA.
  4. Vadaskert Clinic for Child and Adolescent Psychiatry Budapest, Hungary.
  5. Department of Clinical and Experimental Medicine, University of Catania Catania, Italy.
  6. Department of Child Psychiatry, Medical University of Warsaw Warsaw, Poland.
  7. Child and Adolescent Psychiatry Clinic, Sismanoglio General Hospital of Attica Athens, Greece.
  8. Molecular Biology and Pathobiochemistry, Institute of Medical Chemistry, Semmelweis University Budapest, Hungary.
  9. Department of Psychiatry, University of Toronto Toronto, ON, Canada.
  10. Genetics and Development Division, Krembil Research Institute, University Health NetworkToronto, ON, Canada; Program in Neurosciences and Mental Health, The Hospital for Sick ChildrenToronto, ON, Canada.
  11. Department of Molecular Biology and Genetics, Democritus University of ThraceAlexandroupoli, Greece; Laboratory of General Biology, Department of Medicine, Aristotle University of ThessalonikiThessaloniki, Greece.

PMID: 27708560 PMCID: PMC5030307 DOI: 10.3389/fnins.2016.00428

Abstract

Although the genetic basis of Tourette Syndrome (TS) remains unclear, several candidate genes have been implicated. Using a set of 382 TS individuals of European ancestry we investigated four candidate genes for TS (

Keywords: HDC; SLITRK1; TS candidate genes; genetic susceptibility; next generation sequencing; rare variants; targeted re-sequencing

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