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Gaceb A, Vergori L, Martinez MC, et al. Activation of Endothelial Pro-resolving Anti-Inflammatory Pathways by Circulating Microvesicles from Non-muscular Myosin Light Chain Kinase-Deficient Mice. Front Pharmacol. 2016;7:322doi: 10.3389/fphar.2016.00322.
Gaceb, A., Vergori, L., Martinez, M. C., & Andriantsitohaina, R. (2016). Activation of Endothelial Pro-resolving Anti-Inflammatory Pathways by Circulating Microvesicles from Non-muscular Myosin Light Chain Kinase-Deficient Mice. Frontiers in pharmacology, 7322. https://doi.org/10.3389/fphar.2016.00322
Gaceb, Abderahim, et al. "Activation of Endothelial Pro-resolving Anti-Inflammatory Pathways by Circulating Microvesicles from Non-muscular Myosin Light Chain Kinase-Deficient Mice." Frontiers in pharmacology vol. 7 (2016): 322. doi: https://doi.org/10.3389/fphar.2016.00322
Gaceb A, Vergori L, Martinez MC, Andriantsitohaina R. Activation of Endothelial Pro-resolving Anti-Inflammatory Pathways by Circulating Microvesicles from Non-muscular Myosin Light Chain Kinase-Deficient Mice. Front Pharmacol. 2016 Sep 21;7:322. doi: 10.3389/fphar.2016.00322. eCollection 2016. PMID: 27708581; PMCID: PMC5030219.
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Front Pharmacol. 2016 Sep 21;7:322. doi: 10.3389/fphar.2016.00322. eCollection 2016.

Activation of Endothelial Pro-resolving Anti-Inflammatory Pathways by Circulating Microvesicles from Non-muscular Myosin Light Chain Kinase-Deficient Mice.

Frontiers in pharmacology

Abderahim Gaceb, Luisa Vergori, M C Martinez, Ramaroson Andriantsitohaina

Affiliations

  1. INSERM U1063, Université d'Angers Angers, France.
  2. INSERM U1063, Université d'AngersAngers, France; Centre Hospitalo-Universitaire d'AngersAngers, France.

PMID: 27708581 PMCID: PMC5030219 DOI: 10.3389/fphar.2016.00322

Abstract

Microvesicles, small membrane vesicles released from cells, have beneficial and/or deleterious effects in sepsis. We previously reported that non-muscle myosin light chain kinase (nmMLCK) deletion protects mice against endotoxic shock by reducing inflammation. Here, we have evaluated the consequences of nmMLCK deletion on microvesicle phenotypes and their effects on mouse aortic endothelial cells in association with vascular inflammation and endothelial dysfunction during endotoxic shock induced by lipopolysaccharide in mice. Treatment with lipopolysaccharide induced an increase in levels of circulating microvesicles in wild type but not in nmMLCK-deficient mice. Microvesicles from nmMLCK-deficient mice (MVs

Keywords: endothelial cells; extracellular vesicles; lipopolysaccharide; nmMLCK

References

  1. Nephron Exp Nephrol. 2011;119(3):e58-66 - PubMed
  2. J Leukoc Biol. 2008 Mar;83(3):536-45 - PubMed
  3. J Cell Biol. 1998 Feb 9;140(3):627-36 - PubMed
  4. Blood. 2008 Sep 15;112(6):2512-9 - PubMed
  5. Mol Biol Cell. 2011 Mar 1;22(5):634-50 - PubMed
  6. J Atheroscler Thromb. 2005;12(3):138-42 - PubMed
  7. Circ Res. 2011 May 13;108(10):1284-97 - PubMed
  8. Blood. 2000 Feb 1;95(3):930-5 - PubMed
  9. Curr Biol. 2009 Dec 1;19(22):1875-85 - PubMed
  10. Am J Pathol. 2007 Feb;170(2):439-46 - PubMed
  11. Crit Care Med. 2009 Jun;37(6):2045-50 - PubMed
  12. J Biol Chem. 2002 Sep 20;277(38):35597-604 - PubMed
  13. Am J Respir Crit Care Med. 2008 Dec 1;178(11):1148-55 - PubMed
  14. Lancet. 2005 Jan 1-7;365(9453):63-78 - PubMed
  15. Biochem Biophys Res Commun. 2016 Jan 22;469(4):917-22 - PubMed
  16. Am J Respir Cell Mol Biol. 1998 Nov;19(5):758-66 - PubMed
  17. Clin Sci (Lond). 2015 Oct 1;129(8):687-98 - PubMed
  18. J Intern Med. 2000 Mar;247(3):349-58 - PubMed
  19. EMBO Mol Med. 2014 Jan;6(1):27-42 - PubMed
  20. Best Pract Res Clin Anaesthesiol. 2004 Sep;18(3):385-405 - PubMed
  21. PLoS One. 2013 Sep 03;8(9):e73088 - PubMed
  22. Biochimie. 2013 Aug;95(8):1620-8 - PubMed
  23. Am J Physiol Gastrointest Liver Physiol. 2005 Mar;288(3):G422-30 - PubMed
  24. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6233-8 - PubMed
  25. Exp Cell Res. 2004 Aug 15;298(2):407-17 - PubMed
  26. J Trauma. 2002 Mar;52(3):443-8 - PubMed
  27. J Surg Res. 2011 Mar;166(1):32-9 - PubMed
  28. PLoS One. 2014 Mar 19;9(3):e91597 - PubMed
  29. Am J Respir Crit Care Med. 2010 Jul 15;182(2):261-8 - PubMed
  30. Immunity. 2001 Nov;15(5):825-35 - PubMed
  31. Crit Care Med. 2011 Jul;39(7):1739-48 - PubMed
  32. Blood. 2004 Oct 15;104(8):2543-8 - PubMed
  33. J Biol Chem. 1999 Feb 26;274(9):5987-94 - PubMed
  34. Ann N Y Acad Sci. 2008 Mar;1123:134-45 - PubMed
  35. Cardiovasc Res. 2010 Jul 15;87(2):272-80 - PubMed
  36. Crit Care Med. 2005 Nov;33(11):2540-6 - PubMed

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