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Front Physiol. 2016 Sep 21;7:409. doi: 10.3389/fphys.2016.00409. eCollection 2016.

[No title available]

Frontiers in physiology

Anna Dimitrova, Martin Walko, Maryam Hashemi Shabestari, Pravin Kumar, Martina Huber, Armagan Kocer

Affiliations

  1. Department of Biochemistry, University of Groningen Groningen, Netherlands.
  2. Huygens-Kamerlingh Onnes Laboratory, Department of Physics, Leiden University Leiden, Netherlands.
  3. Neuroscience Department, University of Groningen, University Medical Center Groningen Groningen, Netherlands.

PMID: 27708587 PMCID: PMC5030285 DOI: 10.3389/fphys.2016.00409

Abstract

Understanding the functioning of ion channels, as well as utilizing their properties for biochemical applications requires control over channel activity. Herein we report a reversible control over the functioning of a mechanosensitive ion channel by interfering with its interaction with the lipid bilayer. The mechanosensitive channel of large conductance from

Keywords: MscL; bovine serum albumin; electron spin resonance spectroscopy; lysophosphatidylcholines; mechanosensation; reversible gating

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