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Hanken K, Bosse M, Möhrke K, et al. Counteracting Fatigue in Multiple Sclerosis with Right Parietal Anodal Transcranial Direct Current Stimulation. Front Neurol. 2016;7:154doi: 10.3389/fneur.2016.00154.
Hanken, K., Bosse, M., Möhrke, K., Eling, P., Kastrup, A., Antal, A., & Hildebrandt, H. (2016). Counteracting Fatigue in Multiple Sclerosis with Right Parietal Anodal Transcranial Direct Current Stimulation. Frontiers in neurology, 7154. https://doi.org/10.3389/fneur.2016.00154
Hanken, Katrin, et al. "Counteracting Fatigue in Multiple Sclerosis with Right Parietal Anodal Transcranial Direct Current Stimulation." Frontiers in neurology vol. 7 (2016): 154. doi: https://doi.org/10.3389/fneur.2016.00154
Hanken K, Bosse M, Möhrke K, Eling P, Kastrup A, Antal A, Hildebrandt H. Counteracting Fatigue in Multiple Sclerosis with Right Parietal Anodal Transcranial Direct Current Stimulation. Front Neurol. 2016 Sep 21;7:154. doi: 10.3389/fneur.2016.00154. eCollection 2016. PMID: 27708612; PMCID: PMC5030283.
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Front Neurol. 2016 Sep 21;7:154. doi: 10.3389/fneur.2016.00154. eCollection 2016.

Counteracting Fatigue in Multiple Sclerosis with Right Parietal Anodal Transcranial Direct Current Stimulation.

Frontiers in neurology

Katrin Hanken, Mona Bosse, Kim Möhrke, Paul Eling, Andreas Kastrup, Andrea Antal, Helmut Hildebrandt

Affiliations

  1. Department of Psychology, Carl von Ossietzky University Oldenburg, Oldenburg, Germany; Department of Neurology, Klinikum Bremen-Ost, Bremen, Germany.
  2. Department of Psychology, Carl von Ossietzky University Oldenburg , Oldenburg , Germany.
  3. Department of Chemistry, Carl von Ossietzky University Oldenburg , Oldenburg , Germany.
  4. Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen , Nijmegen , Netherlands.
  5. Department of Neurology, Klinikum Bremen-Ost , Bremen , Germany.
  6. University Medical Center, Georg-August University Göttingen , Göttingen , Germany.

PMID: 27708612 PMCID: PMC5030283 DOI: 10.3389/fneur.2016.00154

Abstract

BACKGROUND: Fatigue in multiple sclerosis (MS) patients appears to correlate with vigilance decrement as reflected in an increase in reaction time (RT) and errors with prolonged time-on-task.

OBJECTIVES: The aim of this study was to investigate whether anodal transcranial direct current stimulation (tDCS) over the right parietal or frontal cortex counteracts fatigue-associated vigilance decrement and subjective fatigue.

METHODS: In study I, a randomized double-blind placebo-controlled study, anodal tDCS (1.5 mA) was delivered to the right parietal cortex or the right frontal cortex of 52 healthy participants during the first 20 min of a 40-min lasting visual vigilance task. Study II, also a randomized double-blind placebo-controlled study, investigated the effect of anodal tDCS (1.5 mA) over the right parietal cortex in 46 MS patients experiencing cognitive fatigue. tDCS was delivered for 20 min before patients performed a 20-min lasting visual vigilance task.

RESULTS: Study I showed that right parietal stimulation, but not right frontal stimulation, counteracts the increase in RT associated with vigilance decrement. Hence, only right parietal stimulation was applied to the MS patients in study II. Stimulation had a significant effect on vigilance decrement in mildly to moderately cognitively fatigued MS patients. Vigilance testing significantly increased the feeling of fatigue independent of stimulation.

CONCLUSION: Anodal tDCS over the right parietal cortex can counteract the increase in RTs during vigilance performance, but not the increase in subjective fatigue. This finding is compatible with our model of fatigue in MS, suggesting a dissociation between the feeling and the behavioral characteristics of fatigue.

Keywords: anodal tDCS; multiple sclerosis; right frontal cortex; right parietal cortex; subjective fatigue; vigilance decrement

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