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Queiroz MT, Pereira VG, do Nascimento CC, et al. The Underexploited Role of Non-Coding RNAs in Lysosomal Storage Diseases. Front Endocrinol (Lausanne). 2016;7:133doi: 10.3389/fendo.2016.00133.
Queiroz, M. T., Pereira, V. G., do Nascimento, C. C., & D'Almeida, V. (2016). The Underexploited Role of Non-Coding RNAs in Lysosomal Storage Diseases. Frontiers in endocrinology, 7133. https://doi.org/10.3389/fendo.2016.00133
Queiroz, Matheus Trovão, et al. "The Underexploited Role of Non-Coding RNAs in Lysosomal Storage Diseases." Frontiers in endocrinology vol. 7 (2016): 133. doi: https://doi.org/10.3389/fendo.2016.00133
Queiroz MT, Pereira VG, do Nascimento CC, D'Almeida V. The Underexploited Role of Non-Coding RNAs in Lysosomal Storage Diseases. Front Endocrinol (Lausanne). 2016 Sep 21;7:133. doi: 10.3389/fendo.2016.00133. eCollection 2016. PMID: 27708618; PMCID: PMC5030823.
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Front Endocrinol (Lausanne). 2016 Sep 21;7:133. doi: 10.3389/fendo.2016.00133. eCollection 2016.

The Underexploited Role of Non-Coding RNAs in Lysosomal Storage Diseases.

Frontiers in endocrinology

Matheus Trovão Queiroz, Vanessa Gonçalves Pereira, Cinthia Castro do Nascimento, Vânia D'Almeida

Affiliations

  1. Laboratório de Erros Inatos do Metabolismo, Department of Psychobiology, Universidade Federal de São Paulo , São Paulo , Brazil.
  2. Laboratório de Erros Inatos do Metabolismo, Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil; Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.

PMID: 27708618 PMCID: PMC5030823 DOI: 10.3389/fendo.2016.00133

Abstract

Non-coding RNAs (ncRNAs) are a functional class of RNA involved in the regulation of several cellular processes which may modulate disease onset, progression, and prognosis. Lysosomal storage diseases (LSD) are a group of rare disorders caused by mutations of genes encoding specific hydrolases or non-enzymatic proteins, characterized by a wide spectrum of manifestations. The alteration of ncRNA levels is well established in several human diseases such as cancer and auto-immune disorders; however, there is a lack of information focused on the role of ncRNA in rare diseases. Recent reports related to changes in ncRNA expression and its consequences on LSD physiopathology show us the importance to keep advancing in this field. This article will summarize recent findings and provide key points for further studies on LSD and ncRNA association.

Keywords: lysosomal storage disease; lysosome; miRNA; non-coding RNA; siRNA

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