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Kayani WK, Dilshad E, Ahmed T, et al. Evaluation of Ajuga bracteosa for antioxidant, anti-inflammatory, analgesic, antidepressant and anticoagulant activities. BMC Complement Altern Med. 2016;16(1):375doi: 10.1186/s12906-016-1363-y.
Kayani, W. K., Dilshad, E., Ahmed, T., Ismail, H., & Mirza, B. (2016). Evaluation of Ajuga bracteosa for antioxidant, anti-inflammatory, analgesic, antidepressant and anticoagulant activities. BMC complementary and alternative medicine, 16(1), 375. https://doi.org/10.1186/s12906-016-1363-y
Kayani, Waqas Khan, et al. "Evaluation of Ajuga bracteosa for antioxidant, anti-inflammatory, analgesic, antidepressant and anticoagulant activities." BMC complementary and alternative medicine vol. 16,1 (2016): 375. doi: https://doi.org/10.1186/s12906-016-1363-y
Kayani WK, Dilshad E, Ahmed T, Ismail H, Mirza B. Evaluation of Ajuga bracteosa for antioxidant, anti-inflammatory, analgesic, antidepressant and anticoagulant activities. BMC Complement Altern Med. 2016 Sep 27;16(1):375. doi: 10.1186/s12906-016-1363-y. PMID: 27677846; PMCID: PMC5039935.
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BMC Complement Altern Med. 2016 Sep 27;16(1):375. doi: 10.1186/s12906-016-1363-y.

Evaluation of Ajuga bracteosa for antioxidant, anti-inflammatory, analgesic, antidepressant and anticoagulant activities.

BMC complementary and alternative medicine

Waqas Khan Kayani, Erum Dilshad, Tanveer Ahmed, Hammad Ismail, Bushra Mirza

Affiliations

  1. Department of Botany, The University of Poonch, Rawalakot, Azad Jammu and Kashmir, 12350, Pakistan.
  2. Department of Bioinformatics and Biosciences, Capital University of Science and Technology, Islamabad, Pakistan.
  3. Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
  4. Department of Biochemistry and Molecular Biology, University of Gujrat, 50700, Gujrat, Pakistan.
  5. Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan. [email protected].

PMID: 27677846 PMCID: PMC5039935 DOI: 10.1186/s12906-016-1363-y

Abstract

BACKGROUND: Ajuga bracteosa has been extensively used traditionally for the treatment of a variety of diseases. The aim of the study was to scientifically validate the wide-scale exploitation of A. bracteosa in folk medicine various in vitro and in vivo assays. Moreover, these activities were related to the intrinsic biologically active phytoecdysteroids of A. bracteosa.

METHODS: Aerial and root parts of A. bracteosa were first extracted separately with chloroform (AbCA and AbCR) and the residue was again extracted with methanol (AbMA and AbMR). Total flavonoid and phenolic contents were assayed as quercetin (QE) and gallic acid equivalents (GAE), respectively. These extracts were analyzed for in vitro antioxidant assessment including DPPH and H

RESULTS: AbMA represented highest values of flavonoids (QE 1.98 % DW) and phenolic contents (GAE 5.94 % DW), significantly scavenged DPPH radicles (IC

CONCLUSION: Based on the tested in vitro and in vivo activities, AbMA was found to be a promising bioactive extract. These activities can be attributed to the intrinsic polyphenols and phytoecdysteroids contents of A. bracteosa.

Keywords: Ajuga bracteosa; Anti-inflammatory; Antidepressant; Antioxidants; Phytoecdysteroids; RP-HPLC

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