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Sugioka DK, Gonçalves CE, Bicalho MD. KIR repertory in patients with hematopoietic diseases and healthy family members. BMC Hematol. 2016;16:25doi: 10.1186/s12878-016-0064-6.
Sugioka, D. K., Gonçalves, C. E., & Bicalho, M. D. (2016). KIR repertory in patients with hematopoietic diseases and healthy family members. BMC hematology, 1625. https://doi.org/10.1186/s12878-016-0064-6
Sugioka, Daniele Kazue, et al. "KIR repertory in patients with hematopoietic diseases and healthy family members." BMC hematology vol. 16 (2016): 25. doi: https://doi.org/10.1186/s12878-016-0064-6
Sugioka DK, Gonçalves CE, Bicalho MD. KIR repertory in patients with hematopoietic diseases and healthy family members. BMC Hematol. 2016 Sep 29;16:25. doi: 10.1186/s12878-016-0064-6. eCollection 2016. PMID: 27708784; PMCID: PMC5041293.
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BMC Hematol. 2016 Sep 29;16:25. doi: 10.1186/s12878-016-0064-6. eCollection 2016.

KIR repertory in patients with hematopoietic diseases and healthy family members.

BMC hematology

Daniele Kazue Sugioka, Carlos Eduardo Ibaldo Gonçalves, Maria da Graça Bicalho

Affiliations

  1. Departamento de Genética, Laboratório de Imunogenética e Histocompatibilidade (LIGH), Universidade Federal do Paraná, R. Cel. Francisco H. dos Santos S/N, Centro Politécnico - Jardim das Américas, CEP 81.530.990, Curitiba, PR CP 19071 Brazil.

PMID: 27708784 PMCID: PMC5041293 DOI: 10.1186/s12878-016-0064-6

Abstract

BACKGROUND: Since the discovery of specific histocompatibility, literature has associated genes involved in the immune response, like the Human Leucocyte Antigen (HLA), with a better prognosis in transplantation. However, other non-HLA genes may also influence the immune process, such as the genes encoding the immunoglobulin-like receptors of natural killer cells (KIRs). The discovery that NK cell KIR receptors interact with conservative epitopes (C1, C2, Bw4) presented in HLA class I molecules that are genetically polymorphic, also observed in KIR genes, led to the investigation of the relevance of the KIR system to hematopoietic stem cell transplant. The cure of patients with leukemias and other hematological malignancies after bone marrow transplantation (BMT) has been attributed in part to the ability of the donor immune cells, present in the graft, to recognize and eliminate neoplastic cells of the patient. The cytotoxic activity of NK cells is mediated by the absence of HLA class I-specific ligands on the target cell surface to inhibitory KIR receptors (hypothesis of "missing-self").

METHODS: We analyzed, by PCR typing-SSOP technique, the presence or absence of 16 KIR genes and haplotypes of 39 patients with hematopoietic disorders and 136 healthy individuals from Paraná State. The comparisons made between the patient and control group were performed using χ

RESULTS: Framework genes

CONCLUSION: Our data suggests that susceptibility to leukemia can be influenced, at least, partly byKIR receptors.

Keywords: HLA; KIR; Leukemia

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