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Eur J Rheumatol. 2014 Mar;1(1):21-33. doi: 10.5152/eurjrheum.2014.006. Epub 2014 Mar 01.

Familial Mediterranean fever: An updated review.

European journal of rheumatology

İsmail Sarı, Merih Birlik, Timuçin Kasifoğlu

Affiliations

  1. Department of Internal Medicine, Division of Rheumatology, Dokuz Eylül University Faculty of Medicine, ?zmir, Turkey.
  2. Department of Internal Medicine, Division of Rheumatology, Osmangazi University Faculty of Medicine, Eski?ehir, Turkey.

PMID: 27708867 PMCID: PMC5042258 DOI: 10.5152/eurjrheum.2014.006

Abstract

Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disorder characterised by acute attacks of fever and serosal inflammation. FMF primarily affects Jewish, Armenian, Turkish, and Arab populations. The disease is accompanied by a marked decrease in quality of life due to the effects of attacks and subclinical inflammation in the attack-free periods. Untreated or inadequately treated patients run the risk of amyloidosis, which is an important cause of morbidity and mortality. In this review, the current information available on FMF is summarised.

Keywords: Familial Mediterranean fever; aetiology; amyloidosis; review; treatment

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