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Chem Commun (Camb). 2016 Sep 22;52(78):11701-11703. doi: 10.1039/c6cc05376a.

A six-step total synthesis of α-thujone and d.

Chemical communications (Cambridge, England)

Irene Thamm, Johannes Richers, Michael Rychlik, Konrad Tiefenbacher

Affiliations

  1. Analytical Food Chemistry, Technische Universität München, Alte Akademie 10, 85354 Freising, Germany.
  2. Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85747 Garching, Germany.
  3. Department of Chemistry, University of Basel, St. Johannsring 19, CH-4056 Basel, Switzerland. [email protected] and Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland. [email protected].

PMID: 27709180 DOI: 10.1039/c6cc05376a

Abstract

The short synthesis of α-thujone relies on the functionalization of the readily available dimethylfulvene. Furthermore, the three main metabolites of the natural product were also synthesized. Since d

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