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Jiang H, Chen J, Gao R, et al. Liver fibrosis staging with diffusion-weighted imaging: a systematic review and meta-analysis. Abdom Radiol (NY). 2017;42(2):490-501doi: 10.1007/s00261-016-0913-6.
Jiang, H., Chen, J., Gao, R., Huang, Z., Wu, M., & Song, B. (2017). Liver fibrosis staging with diffusion-weighted imaging: a systematic review and meta-analysis. Abdominal radiology (New York), 42(2), 490-501. https://doi.org/10.1007/s00261-016-0913-6
Jiang, Hanyu, et al. "Liver fibrosis staging with diffusion-weighted imaging: a systematic review and meta-analysis." Abdominal radiology (New York) vol. 42,2 (2017): 490-501. doi: https://doi.org/10.1007/s00261-016-0913-6
Jiang H, Chen J, Gao R, Huang Z, Wu M, Song B. Liver fibrosis staging with diffusion-weighted imaging: a systematic review and meta-analysis. Abdom Radiol (NY). 2017 Feb;42(2):490-501. doi: 10.1007/s00261-016-0913-6. PMID: 27678393.
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Abdom Radiol (NY). 2017 Feb;42(2):490-501. doi: 10.1007/s00261-016-0913-6.

Liver fibrosis staging with diffusion-weighted imaging: a systematic review and meta-analysis.

Abdominal radiology (New York)

Hanyu Jiang, Jie Chen, Ronghui Gao, Zixing Huang, Mingpeng Wu, Bin Song

Affiliations

  1. Department of Radiology, Sichuan University West China Hospital, No. 37 Guoxue Alley, Chengdu, Sichuan, China.
  2. Department of Radiology, Sichuan University West China Hospital, No. 37 Guoxue Alley, Chengdu, Sichuan, China. [email protected].

PMID: 27678393 DOI: 10.1007/s00261-016-0913-6

Abstract

PURPOSE: A meta-analysis was performed to assess the diagnostic performance of diffusion-weighted imaging (DWI) in liver fibrosis (LF) staging.

METHODS: We conducted a comprehensive literature search to identify relevant articles. Diagnostic data were extracted for each METAVIR fibrosis stage (F0-F4). A bivariate binomial model was used to combine sensitivities and specificities. Summary receiver operating characteristics (SROC) curves were performed and areas under SROC curve (AUC) were calculated to indicate diagnostic accuracies. Subgroup analyses were performed between different study characteristics.

RESULTS: Twelve studies met the inclusion criteria for LF ≥F1, 16 for ≥F2, 18 for ≥F3, and 12 for F4. AUCs of DWI were 0.8554, 0.8770, 0.8836, and 0.8596 for ≥F1, ≥F2, ≥F3, and F4, respectively. Subgroup analyses showed that for LF ≥F2 and ≥F3, maximal b values (b

CONCLUSIONS: DWI is a reliable noninvasive technique with good diagnostic accuracy for LF staging. Using b

Keywords: Diffusion magnetic resonance imaging; Liver cirrhosis; Meta-analysis; Sensitivity; Specificity

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