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Delanaye P, Melsom T, Ebert N, et al. Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol?. Clin Kidney J. 2016;9(5):700-4doi: 10.1093/ckj/sfw071.
Delanaye, P., Melsom, T., Ebert, N., Bäck, S. E., Mariat, C., Cavalier, E., Björk, J., Christensson, A., Nyman, U., Porrini, E., Remuzzi, G., Ruggenenti, P., Schaeffner, E., Soveri, I., Sterner, G., Eriksen, B. O., & Gaspari, F. (2016). Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol?. Clinical kidney journal, 9(5), 700-4. https://doi.org/10.1093/ckj/sfw071
Delanaye, Pierre, et al. "Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol?." Clinical kidney journal vol. 9,5 (2016): 700-4. doi: https://doi.org/10.1093/ckj/sfw071
Delanaye P, Melsom T, Ebert N, Bäck SE, Mariat C, Cavalier E, Björk J, Christensson A, Nyman U, Porrini E, Remuzzi G, Ruggenenti P, Schaeffner E, Soveri I, Sterner G, Eriksen BO, Gaspari F. Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol?. Clin Kidney J. 2016 Oct;9(5):700-4. doi: 10.1093/ckj/sfw071. Epub 2016 Sep 09. PMID: 27679716; PMCID: PMC5036903.
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Clin Kidney J. 2016 Oct;9(5):700-4. doi: 10.1093/ckj/sfw071. Epub 2016 Sep 09.

Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol?.

Clinical kidney journal

Pierre Delanaye, Toralf Melsom, Natalie Ebert, Sten-Erik Bäck, Christophe Mariat, Etienne Cavalier, Jonas Björk, Anders Christensson, Ulf Nyman, Esteban Porrini, Giuseppe Remuzzi, Piero Ruggenenti, Elke Schaeffner, Inga Soveri, Gunnar Sterner, Bjørn Odvar Eriksen, Flavio Gaspari

Affiliations

  1. Department of Nephrology, Dialysis and Transplantation , University of Liège Hospital (ULg CHU) , 4000 Liège , Belgium.
  2. Metabolic and Renal Research Group , UiT The Arctic University of Norway and Section of Nephrology, University Hospital of North Norway , Tromsø , Norway.
  3. Charité University Medicine, Institute of Public Health, Berlin , Germany.
  4. Department of Clinical Chemistry , Skåne University Hospital , Lund , Sweden.
  5. Department of Nephrology, Dialysis, Transplantation and Hypertension , CHU Hôpital Nord, University Jean Monnet, PRES Université de LYON , Saint-Etienne , France.
  6. Department of Clinical Chemistry , University of Liège Hospital (ULg CHU) , Liège , Belgium.
  7. Department of Occupational and Environmental Medicine , Lund University , Lund , Sweden.
  8. Department of Nephrology , Skåne University Hospital , Lund , Sweden.
  9. Department of Translational Medicine, Division of Medical Radiology , Skåne University Hospital , Malmö , Sweden.
  10. University of La Laguna, CIBICAN-ITB, Faculty of Medicine, Hospital Universtario de Canarias , Tenerife , Spain.
  11. Centro di Ricerche Cliniche per le Malattie Rare 'Aldo e Cele Daccò', Istituto di Ricerche Farmacologiche Mario Negri, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy; Unit of Nephrology, Azienda Socio Sanitaria Territoriale (ASST) Ospedale Papa Giovanni XXIII, Bergamo, Italy.
  12. Department of Medical Sciences , Uppsala University , Uppsala , Sweden.
  13. Department of Nephrology , Skåne University Hospital , Malmö , Sweden.
  14. IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri', Centro di Ricerche Cliniche per le Malattie Rare 'Aldo e Cele Daccò', Ranica, Bergamo, Italy.

PMID: 27679716 PMCID: PMC5036903 DOI: 10.1093/ckj/sfw071

Abstract

A reliable assessment of glomerular filtration rate (GFR) is of paramount importance in clinical practice as well as epidemiological and clinical research settings. It is recommended by Kidney Disease: Improving Global Outcomes guidelines in specific populations (anorectic, cirrhotic, obese, renal and non-renal transplant patients) where estimation equations are unreliable. Measured GFR is the only valuable test to confirm or confute the status of chronic kidney disease (CKD), to evaluate the slope of renal function decay over time, to assess the suitability of living kidney donors and for dosing of potentially toxic medication with a narrow therapeutic index. Abnormally elevated GFR or hyperfiltration in patients with diabetes or obesity can be correctly diagnosed only by measuring GFR. GFR measurement contributes to assessing the true CKD prevalence rate, avoiding discrepancies due to GFR estimation with different equations. Using measured GFR, successfully accomplished in large epidemiological studies, is the only way to study the potential link between decreased renal function and cardiovascular or total mortality, being sure that this association is not due to confounders, i.e. non-GFR determinants of biomarkers. In clinical research, it has been shown that measured GFR (or measured GFR slope) as a secondary endpoint as compared with estimated GFR detected subtle treatment effects and obtained these results with a comparatively smaller sample size than trials choosing estimated GFR. Measuring GFR by iohexol has several advantages: simplicity, low cost, stability and low interlaboratory variation. Iohexol plasma clearance represents the best chance for implementing a standardized GFR measurement protocol applicable worldwide both in clinical practice and in research.

Keywords: glomerular filtration rate; iohexol

References

  1. Nephron Clin Pract. 2008;110(3):c158-63 - PubMed
  2. Lancet. 2013 Nov 2;382(9903):1485-95 - PubMed
  3. N Engl J Med. 2013 Sep 5;369(10):932-43 - PubMed
  4. Am J Kidney Dis. 2016 Jun;67(6):841-50 - PubMed
  5. PLoS One. 2012;7(2):e32533 - PubMed
  6. Curr Opin Nephrol Hypertens. 2008 May;17(3):286-91 - PubMed
  7. J Am Soc Nephrol. 2002 Nov;13(11):2811-2; author reply 2812-6 - PubMed
  8. Adv Chronic Kidney Dis. 2015 Sep;22(5):337-42 - PubMed
  9. Ann Pharmacother. 2012 Sep;46(9):1174-87 - PubMed
  10. Transplantation. 2015 Dec;99(12):2625-33 - PubMed
  11. JAMA. 2012 Dec 12;308(22):2349-60 - PubMed
  12. Clin Biochem Rev. 2016 Feb;37(1):17-26 - PubMed
  13. JAMA. 2012 May 9;307(18):1941-51 - PubMed
  14. Clin J Am Soc Nephrol. 2015 Nov 6;10 (11):2073-83 - PubMed
  15. N Engl J Med. 2012 Dec 20;367(25):2407-18 - PubMed
  16. Eur J Epidemiol. 2010 Mar;25(3):203-10 - PubMed
  17. J Am Soc Nephrol. 2016 Jul;27(7):2135-47 - PubMed
  18. Clin J Am Soc Nephrol. 2016 Feb 5;11(2):280-6 - PubMed
  19. Ann Intern Med. 2009 May 5;150(9):604-12 - PubMed
  20. Am J Nephrol. 2015;41(1):7-15 - PubMed
  21. Nephrol Dial Transplant. 2016 May;31(5):798-806 - PubMed
  22. Lancet. 2010 Jun 12;375(9731):2073-81 - PubMed
  23. JAMA. 2007 Nov 7;298(17):2038-47 - PubMed
  24. J Am Soc Nephrol. 2009 Nov;20(11):2305-13 - PubMed
  25. Ann Intern Med. 2012 Oct 2;157(7):471-81 - PubMed
  26. Kidney Int. 1996 Jun;49(6):1774-7 - PubMed
  27. Clin J Am Soc Nephrol. 2015 Nov 6;10 (11):1946-55 - PubMed
  28. Antimicrob Agents Chemother. 2011 Sep;55(9):4006-11 - PubMed
  29. N Engl J Med. 2005 Aug 25;353(8):770-81 - PubMed
  30. J Am Soc Nephrol. 2011 May;22(5):927-37 - PubMed
  31. Kidney Int. 2009 Mar;75(6):652-60 - PubMed
  32. Am J Kidney Dis. 2015 Aug;66(2):240-8 - PubMed
  33. Nephrol Dial Transplant. 2013 Nov;28 Suppl 4:iv122-30 - PubMed
  34. Kidney Int. 2003 May;63(5):1944-7 - PubMed
  35. Eur J Cancer. 2002 Jan;38(1):44-51 - PubMed
  36. Kidney Int. 2004 Apr;65(4):1416-21 - PubMed
  37. Kidney Int. 2013 Jun;83(6):1169-76 - PubMed
  38. Nat Rev Nephrol. 2013 Sep;9(9):513-22 - PubMed
  39. Am J Transplant. 2007 Apr;7(4):880-7 - PubMed
  40. J Am Soc Nephrol. 2011 Oct;22(10):1931-7 - PubMed
  41. Br J Clin Pharmacol. 2016 Feb;81(2):349-61 - PubMed
  42. Obesity (Silver Spring). 2009 Dec;17(12):2121-6 - PubMed
  43. Kidney Int. 2013 Jul;84(1):164-73 - PubMed
  44. Diabetes Care. 2012 Oct;35(10):2061-8 - PubMed
  45. Clin Chem. 1992 Oct;38(10):1933-53 - PubMed
  46. Nephrol Dial Transplant. 2015 Aug;30 Suppl 4:iv6-16 - PubMed
  47. BMC Nephrol. 2013 Mar 12;14:57 - PubMed
  48. Nephron Clin Pract. 2010;115(1):c41-50 - PubMed
  49. J Am Soc Nephrol. 2011 Aug;22(8):1517-25 - PubMed
  50. Am J Physiol Renal Physiol. 2000 May;278(5):F817-22 - PubMed
  51. BMJ Open. 2015 Jun 23;5(6):e008188 - PubMed
  52. Transplantation. 2013 May 27;95(10):1211-7 - PubMed
  53. JAMA. 2014 Jun 25;311(24):2518-31 - PubMed
  54. J Am Soc Nephrol. 2006 Mar;17(3):854-62 - PubMed
  55. Kidney Int. 2010 Dec;78(12):1305-11 - PubMed
  56. Kidney Int Suppl. 1997 Dec;63:S151-4 - PubMed
  57. Ann Intern Med. 2006 Aug 15;145(4):237-46 - PubMed

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