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Orikasa S, Nabeshima K, Iwabuchi N, et al. Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice. Biosci Microbiota Food Health. 2016;35(3):141-5doi: 10.12938/bmfh.2016-004.
Orikasa, S., Nabeshima, K., Iwabuchi, N., & Xiao, J. Z. (2016). Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice. Bioscience of microbiota, food and health, 35(3), 141-5. https://doi.org/10.12938/bmfh.2016-004
Orikasa, Shuzo, et al. "Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice." Bioscience of microbiota, food and health vol. 35,3 (2016): 141-5. doi: https://doi.org/10.12938/bmfh.2016-004
Orikasa S, Nabeshima K, Iwabuchi N, Xiao JZ. Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice. Biosci Microbiota Food Health. 2016;35(3):141-5. doi: 10.12938/bmfh.2016-004. Epub 2016 May 11. PMID: 27508116; PMCID: PMC4965519.
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Biosci Microbiota Food Health. 2016;35(3):141-5. doi: 10.12938/bmfh.2016-004. Epub 2016 May 11.

Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice.

Bioscience of microbiota, food and health

Shuzo Orikasa, Kazumi Nabeshima, Noriyuki Iwabuchi, Jin-Zhong Xiao

Affiliations

  1. Next Generation Science Institute, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama, Kanagawa 252-8583, Japan.
  2. Food Ingredients and Technology Institute, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama, Kanagawa 252-8583, Japan.

PMID: 27508116 PMCID: PMC4965519 DOI: 10.12938/bmfh.2016-004

Abstract

Schizophrenia is a chronic psychiatric illness. Disruption of the dopaminergic system has been suggested to be the pathogenic cause of this disease. The effect of Bifidobacterium longum BB536 (BB536) on schizophrenic behavior was investigated in an animal model. Daily administration of BB536 (10(9) CFU/mouse, p.o. for 2 weeks) was found to reduce rearing behavior augmented by the dopamine receptor agonist apomorphine and to decrease the resting level of plasma corticosterone and the ratio of kynurenine to tryptophan. These results suggest the potential of BB536 for supplemental treatment of the symptoms of schizophrenia.

Keywords: Bifidobacterium longum BB536; apomorphine; corticosterone; kynurenine; rearing behavior; schizophrenia; tryptophan

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