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Vo E, Palacio CH, Omino R, et al. Solitary colon metastasis from renal cell carcinoma nine years after nephrectomy: A case report. Int J Surg Case Rep. 2016;27:55-58doi: 10.1016/j.ijscr.2016.07.053.
Vo, E., Palacio, C. H., Omino, R., Link, R. E., Sada, Y., & Avo, A. (2016). Solitary colon metastasis from renal cell carcinoma nine years after nephrectomy: A case report. International journal of surgery case reports, 2755-58. https://doi.org/10.1016/j.ijscr.2016.07.053
Vo, Elaine, et al. "Solitary colon metastasis from renal cell carcinoma nine years after nephrectomy: A case report." International journal of surgery case reports vol. 27 (2016): 55-58. doi: https://doi.org/10.1016/j.ijscr.2016.07.053
Vo E, Palacio CH, Omino R, Link RE, Sada Y, Avo A. Solitary colon metastasis from renal cell carcinoma nine years after nephrectomy: A case report. Int J Surg Case Rep. 2016;27:55-58. doi: 10.1016/j.ijscr.2016.07.053. Epub 2016 Aug 03. PMID: 27543725; PMCID: PMC4992005.
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Int J Surg Case Rep. 2016;27:55-58. doi: 10.1016/j.ijscr.2016.07.053. Epub 2016 Aug 03.

Solitary colon metastasis from renal cell carcinoma nine years after nephrectomy: A case report.

International journal of surgery case reports

Elaine Vo, Carlos H Palacio, Ronald Omino, Richard E Link, Yvonne Sada, Artinyan Avo

Affiliations

  1. Baylor College of Medicine, Michael E. DeBakey Department of Surgery, United States.
  2. Baylor College of Medicine, Margaret M. and Albert B. Alkek Department of Medicine, United States.
  3. Baylor College of Medicine, Scott Department of Urology, United States.
  4. Baylor College of Medicine, Margaret M. and Albert B. Alkek Department of Medicine, Section of Hematology-Oncology, United States.
  5. Baylor College of Medicine, Michael E. DeBakey Department of Surgery, Division of Surgical Oncology, United States. Electronic address: [email protected].

PMID: 27543725 PMCID: PMC4992005 DOI: 10.1016/j.ijscr.2016.07.053

Abstract

INTRODUCTION: Renal cell carcinoma (RCC) is the most common renal malignancy in adults. Metastatic disease is relatively common at presentation and frequently involves the lung, bone, brain, liver and adrenal glands. After curative resection, there is a 30-40% risk of recurrence, and a 10% risk of developing metastatic disease after 5 years. The gastrointestinal tract, particularly the colon, represents a very uncommon site of late metastatic disease.

PRESENTATION OF CASE: We present a case of a 67 year-old-male who underwent a left radical nephrectomy for RCC 9 years before presenting with a metastatic large bowel obstruction. He was later found to have a near-completely obstructing mass in the rectosigmoid colon and underwent a sigmoidectomy with anterior resection of the upper rectum. Histopathology confirmed metastatic RCC confined to the colonic wall with negative microscopic margins.

DISCUSSION: The tendency of RCC to metastasize to unusual sites such as the pancreas or thyroid gland has been widely reported. However, cases of colon metastasis from RCC are extremely rare. Despite the absence of randomized prospective data, widespread consensus supports the surgical treatment of solitary and oligometastatic disease in light of the poor patient outcomes in non-surgically treated disease (Milovic et al., 2013) [3]. Multiple groups have reported favorable outcomes for surgically resected solitary metastatic disease with long disease-free intervals and good performance status.

CONCLUSION: The colon is a potential, though uncommon, site for solitary metastasis from RCC. The clinical presentation is frequently several years after initial curative resection. Oncologic resection with negative margins may result in long-term survival in patients with isolated metastatic disease.

Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Keywords: Carcinoma; Neoplasm metastasis; Renal cell

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