Display options
Share it on

Pharmaceuticals (Basel). 2010 Aug 03;3(8):2426-2440. doi: 10.3390/ph3082426.

The Impact of Residual Symptoms in Major Depression.

Pharmaceuticals (Basel, Switzerland)

Joshua A Israel

Affiliations

  1. San Francisco VA Medical Center, University of California San Francisco, 4150 Clement Street, 116N, San Francisco, CA 94121, USA. [email protected].

PMID: 27713362 PMCID: PMC4033933 DOI: 10.3390/ph3082426

Abstract

The current definition of remission from major depressive disorder does not fully take into account all aspects of patient recovery. Residual symptoms of depression are very common in patients who are classified as being in remission. Patients with residual symptoms are at increased risk of functional and interpersonal impairments, and are at high risk for recurrence of depression. This article discusses the incidence of residual symptoms of depression, as well as the risks and consequences of these symptoms, and will review the state of current treatment.

Keywords: major depressive disorder, MDD, antidepressive agents, residual symptoms, depression, depression treatment

References

  1. Eur Heart J. 2000 Jul;21(13):1072-80 - PubMed
  2. Am J Psychiatry. 2006 Jan;163(1):28-40 - PubMed
  3. Curr Psychiatry Rep. 2005 Dec;7(6):435-40 - PubMed
  4. J Clin Psychiatry. 1999 Apr;60(4):221-5 - PubMed
  5. Psychol Med. 2003 Jul;33(5):827-38 - PubMed
  6. World J Biol Psychiatry. 2008;9(2):102-14 - PubMed
  7. J Affect Disord. 1998 Sep;50(2-3):97-108 - PubMed
  8. Depress Anxiety. 2008;25(12):1060-6 - PubMed
  9. Acta Psychiatr Scand. 2003 Jul;108(1):15-9 - PubMed
  10. N Engl J Med. 2006 Mar 23;354(12):1231-42 - PubMed
  11. Psychiatry Res. 1990 Jun;32(3):241-51 - PubMed
  12. J Clin Psychiatry. 2003 Sep;64(9):1057-64 - PubMed
  13. Am J Psychiatry. 2006 Jul;163(7):1161-72 - PubMed
  14. Am J Psychiatry. 2008 Jan;165(1):133; author reply 133-4 - PubMed
  15. J Affect Disord. 2004 Jun;80(2-3):135-44 - PubMed
  16. J Clin Psychiatry. 2004 Feb;65(2):217-21 - PubMed
  17. J Clin Psychiatry. 2004;65 Suppl 4:53-9 - PubMed
  18. J Psychiatry Neurosci. 2002 Jul;27(4):241-7 - PubMed
  19. Int Clin Psychopharmacol. 1998 Feb;13 Suppl 2:S13-8 - PubMed
  20. Compr Psychiatry. 2000 Mar-Apr;41(2 Suppl 1):55-60 - PubMed
  21. J Psychopharmacol. 2006 May;20(3 Suppl):35-40 - PubMed
  22. J Clin Psychiatry. 2003 Apr;64(4):397-402 - PubMed
  23. J Clin Psychiatry. 2008 Feb;69(2):246-58 - PubMed
  24. J Clin Psychiatry. 2007 Feb;68(2):254-60 - PubMed
  25. J Clin Psychiatry. 2003;64 Suppl 18:3-7 - PubMed
  26. J Psychopharmacol. 2006 May;20(3 Suppl):5-10 - PubMed
  27. J Clin Psychiatry. 2001;62 Suppl 16:5-9 - PubMed
  28. Arch Gen Psychiatry. 1991 Sep;48(9):851-5 - PubMed
  29. Am J Psychiatry. 2000 Sep;157(9):1501-4 - PubMed
  30. Am J Psychiatry. 1998 Oct;155(10):1443-5 - PubMed
  31. Arch Gen Psychiatry. 1997 Nov;54(11):1016-24 - PubMed
  32. J Clin Psychiatry. 2006;67 Suppl 6:27-32 - PubMed
  33. J Neurosci. 1999 Jun 15;19(12):5034-43 - PubMed
  34. Am J Psychiatry. 2006 Nov;163(11):1905-17 - PubMed
  35. Neuropsychopharmacology. 2006 Sep;31(9):1841-53 - PubMed
  36. Biol Psychiatry. 1998 Sep 1;44(5):348-60 - PubMed
  37. Depress Anxiety. 1996-1997;4(6):312-9 - PubMed
  38. N Engl J Med. 2007 Nov 8;357(19):1939-45 - PubMed
  39. Pharmacoeconomics. 1995 Dec;8(6):524-40 - PubMed
  40. Am J Psychiatry. 2006 Jan;163(1):148-50 - PubMed
  41. Am J Psychiatry. 1992 Aug;149(8):1046-52 - PubMed
  42. Psychol Med. 1990 May;20(2):375-81 - PubMed
  43. J Clin Psychiatry. 2008 Aug;69(8):1246-56 - PubMed
  44. Am J Psychiatry. 2001 Oct;158(10):1645-51 - PubMed
  45. J Affect Disord. 2004 Oct 15;82(2):291-6 - PubMed
  46. J ECT. 2007 Mar;23(1):1-2 - PubMed
  47. JAMA. 2007 Jul 18;298(3):330-2 - PubMed
  48. J Affect Disord. 2007 Nov;103(1-3):77-82 - PubMed
  49. Arch Gen Psychiatry. 1996 Feb;53(2):99-108 - PubMed
  50. J Affect Disord. 1997 Aug;45(1-2):65-73 - PubMed
  51. Psychosom Med. 2000 Jul-Aug;62(4):463-71 - PubMed
  52. J Clin Psychopharmacol. 1999 Oct;19(5):427-34 - PubMed
  53. Arch Gen Psychiatry. 1983 Dec;40(12):1335-42 - PubMed
  54. Br J Psychiatry. 1994 Mar;164(3):349-54 - PubMed
  55. J Affect Disord. 1990 Jun;19(2):149-52 - PubMed
  56. Br J Psychiatry. 2007 Apr;190:344-9 - PubMed
  57. J Affect Disord. 1997 Aug;45(1-2):5-17; discussion 17-8 - PubMed
  58. Psychother Psychosom. 2006;75(3):139-53 - PubMed
  59. Br J Psychiatry. 2004 Nov;185:372-7 - PubMed
  60. Psychol Psychother. 2007 Jun;80(Pt 2):193-203 - PubMed
  61. JAMA. 1997 Jan 22-29;277(4):333-40 - PubMed
  62. Arch Gen Psychiatry. 1992 Oct;49(10):761-8 - PubMed
  63. Compr Psychiatry. 2000 Mar-Apr;41(2 Suppl 1):1-7 - PubMed
  64. N Engl J Med. 2006 Mar 23;354(12):1243-52 - PubMed
  65. Int J Geriatr Psychiatry. 2005 Dec;20(12):1196-202 - PubMed
  66. Psychother Psychosom. 1994;62(3-4):160-7 - PubMed
  67. J Clin Psychopharmacol. 2002 Aug;22(4):379-87 - PubMed
  68. Eur Psychiatry. 2004 Jun;19(4):209-13 - PubMed
  69. Am J Psychiatry. 1994 Sep;151(9):1295-9 - PubMed
  70. J Clin Psychiatry. 2007;68 Suppl 10:4-7 - PubMed
  71. J Psychiatr Res. 2003 Jan-Feb;37(1):9-15 - PubMed
  72. Psychol Med. 1995 Nov;25(6):1171-80 - PubMed
  73. Neuropsychiatr Dis Treat. 2007 Dec;3(6):735-43 - PubMed
  74. Arch Gen Psychiatry. 1990 Dec;47(12):1100-5 - PubMed
  75. Am J Psychiatry. 2003 Apr;160(4):734-40 - PubMed
  76. Curr Psychiatry Rep. 2007 Dec;9(6):449-59 - PubMed
  77. N Engl J Med. 2008 Jan 3;358(1):55-68 - PubMed
  78. Am J Psychiatry. 2006 Sep;163(9):1519-30; quiz 1665 - PubMed
  79. Acta Psychiatr Scand Suppl. 2002;(415):7-11 - PubMed
  80. Am J Psychiatry. 2006 Jul;163(7):1219-25 - PubMed
  81. J Clin Psychiatry. 2005 May;66(5):603-10 - PubMed
  82. JAMA. 2003 Jun 18;289(23):3152-60 - PubMed
  83. Compr Psychiatry. 2007 Mar-Apr;48(2):113-7 - PubMed
  84. Depress Anxiety. 2008;25(6):E27-36 - PubMed
  85. Biol Psychiatry. 2002 Jan 15;51(2):183-8 - PubMed
  86. J Clin Psychiatry. 2008;69 Suppl 1:32-44 - PubMed
  87. J Clin Psychiatry. 2005 Oct;66(10):1326-30 - PubMed

Publication Types