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Camacho-Muñoz D, Petrie B, Castrignanò E, et al. Enantiomeric Profiling of Chiral Pharmacologically Active Compounds in the Environment with the Usage of Chiral Liquid Chromatography 
Coupled with Tandem Mass Spectrometry. Curr Anal Chem. 2016;12(4):303-314doi: 10.2174/1573411012666151009195039.
Camacho-Muñoz, D., Petrie, B., Castrignanò, E., & Kasprzyk-Hordern, B. (2016). Enantiomeric Profiling of Chiral Pharmacologically Active Compounds in the Environment with the Usage of Chiral Liquid Chromatography 
Coupled with Tandem Mass Spectrometry. Current analytical chemistry, 12(4), 303-314. https://doi.org/10.2174/1573411012666151009195039
Camacho-Muñoz, Dolores, et al. "Enantiomeric Profiling of Chiral Pharmacologically Active Compounds in the Environment with the Usage of Chiral Liquid Chromatography 
Coupled with Tandem Mass Spectrometry." Current analytical chemistry vol. 12,4 (2016): 303-314. doi: https://doi.org/10.2174/1573411012666151009195039
Camacho-Muñoz D, Petrie B, Castrignanò E, Kasprzyk-Hordern B. Enantiomeric Profiling of Chiral Pharmacologically Active Compounds in the Environment with the Usage of Chiral Liquid Chromatography 
Coupled with Tandem Mass Spectrometry. Curr Anal Chem. 2016 Aug;12(4):303-314. doi: 10.2174/1573411012666151009195039. PMID: 27713682; PMCID: PMC5024650.
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Curr Anal Chem. 2016 Aug;12(4):303-314. doi: 10.2174/1573411012666151009195039.

Enantiomeric Profiling of Chiral Pharmacologically Active Compounds in the Environment with the Usage of Chiral Liquid Chromatography 
Coupled with Tandem Mass Spectrometry.

Current analytical chemistry

Dolores Camacho-Muñoz, Bruce Petrie, Erika Castrignanò, Barbara Kasprzyk-Hordern

Affiliations

  1. Department of Chemistry, University of Bath, Bath, United Kingdom.

PMID: 27713682 PMCID: PMC5024650 DOI: 10.2174/1573411012666151009195039

Abstract

The issue of drug chirality is attracting increasing attention among the scientific community. The phenomenon of chirality has been overlooked in environmental research (environmental occurrence, fate and toxicity) despite the great impact that chiral pharmacologically active compounds (cPACs) can provoke on ecosystems. The aim of this paper is to introduce the topic of chirality and its implications in environmental contamination. Special attention has been paid to the most recent advances in chiral analysis based on liquid chromatography coupled with mass spectrometry and the most popular protein based chiral stationary phases. Several groups of cPACs of environmental relevance, such as illicit drugs, human and veterinary medicines were discussed. The increase in the number of papers published in the area of chiral environmental analysis indicates that researchers are actively pursuing new opportunities to provide better understanding of environmental impacts resulting from the enantiomerism of cPACs.

Keywords: Analysis; chiral chromatography; chiral drugs; environment; mass spectrometry; pharmaceuticals; wastewater

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