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Telford R, Seaton CC, Clout A, et al. Stabilisation of metastable polymorphs: the case of paracetamol form III. Chem Commun (Camb). 2016;52(81):12028-12031doi: 10.1039/c6cc05006a.
Telford, R., Seaton, C. C., Clout, A., Buanz, A., Gaisford, S., Williams, G. R., Prior, T. J., Okoye, C. H., Munshi, T., & Scowen, I. J. (2016). Stabilisation of metastable polymorphs: the case of paracetamol form III. Chemical communications (Cambridge, England), 52(81), 12028-12031. https://doi.org/10.1039/c6cc05006a
Telford, Richard, et al. "Stabilisation of metastable polymorphs: the case of paracetamol form III." Chemical communications (Cambridge, England) vol. 52,81 (2016): 12028-12031. doi: https://doi.org/10.1039/c6cc05006a
Telford R, Seaton CC, Clout A, Buanz A, Gaisford S, Williams GR, Prior TJ, Okoye CH, Munshi T, Scowen IJ. Stabilisation of metastable polymorphs: the case of paracetamol form III. Chem Commun (Camb). 2016 Oct 18;52(81):12028-12031. doi: 10.1039/c6cc05006a. Epub 2016 Aug 11. PMID: 27510730.
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Chem Commun (Camb). 2016 Oct 18;52(81):12028-12031. doi: 10.1039/c6cc05006a. Epub 2016 Aug 11.

Stabilisation of metastable polymorphs: the case of paracetamol form III.

Chemical communications (Cambridge, England)

Richard Telford, Colin C Seaton, Alexander Clout, Asma Buanz, Simon Gaisford, Gareth R Williams, Timothy J Prior, Chidera H Okoye, Tasnim Munshi, Ian J Scowen

Affiliations

  1. School of Chemistry and Forensic Sciences, University of Bradford, Richmond Road, Bradford, BD7 1DP, UK.

PMID: 27510730 DOI: 10.1039/c6cc05006a

Abstract

The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising 'active' templates of the metastable polymorph.

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