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Wysocka O, Kulbacka J, Saczko J. Adjuvant, neoadjuvant, and experimental regimens in overcoming pancreatic ductal adenocarcinoma. Prz Gastroenterol. 2016;11(3):155-162doi: 10.5114/pg.2016.61438.
Wysocka, O., Kulbacka, J., & Saczko, J. (2016). Adjuvant, neoadjuvant, and experimental regimens in overcoming pancreatic ductal adenocarcinoma. Przeglad gastroenterologiczny, 11(3), 155-162. https://doi.org/10.5114/pg.2016.61438
Wysocka, Olga, et al. "Adjuvant, neoadjuvant, and experimental regimens in overcoming pancreatic ductal adenocarcinoma." Przeglad gastroenterologiczny vol. 11,3 (2016): 155-162. doi: https://doi.org/10.5114/pg.2016.61438
Wysocka O, Kulbacka J, Saczko J. Adjuvant, neoadjuvant, and experimental regimens in overcoming pancreatic ductal adenocarcinoma. Prz Gastroenterol. 2016;11(3):155-162. doi: 10.5114/pg.2016.61438. Epub 2016 Jul 22. PMID: 27713776; PMCID: PMC5047971.
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Prz Gastroenterol. 2016;11(3):155-162. doi: 10.5114/pg.2016.61438. Epub 2016 Jul 22.

Adjuvant, neoadjuvant, and experimental regimens in overcoming pancreatic ductal adenocarcinoma.

Przeglad gastroenterologiczny

Olga Wysocka, Julita Kulbacka, Jolanta Saczko

Affiliations

  1. Department of Medical Biochemistry, Wroclaw Medical University, Wroclaw, Poland.

PMID: 27713776 PMCID: PMC5047971 DOI: 10.5114/pg.2016.61438

Abstract

Pancreatic cancer is one of the most aggressive and deadly malignancies. Despite better understanding of its biology and pathogenesis, contemporary treatment regimens are still insufficient. Along with the introduction of new treatment agents and combination therapy, the response rates are increasing, but these scores do not go with overall survival, and results are frequently conflicting. Therefore, contemporary medicine faces the challenge of expanding the knowledge base and practice on all grounds - pathology, factor risk, diagnosis, and finally surgical and palliative treatment of this disease. This paper provides a review of current adjuvant and neoadjuvant regimens and the role of experimental therapies in pancreatic ductal adenocarcinoma.

Keywords: epidemiology; pancreatic cancer; treatment

Conflict of interest statement

The authors declare no conflict of interest.

References

  1. Cancer Invest. 2002;20(2):246-63 - PubMed
  2. Cancer J. 2001 Jul-Aug;7(4):266-73 - PubMed
  3. Ann Oncol. 2003 Feb;14(2):205-8 - PubMed
  4. Gastroenterol Hepatol (N Y). 2011 May;7(5):313-6 - PubMed
  5. Technol Cancer Res Treat. 2007 Aug;6(4):255-60 - PubMed
  6. J Surg Oncol. 2015 Jun;111(8):1028-34 - PubMed
  7. JAMA. 2007 Jan 17;297(3):267-77 - PubMed
  8. J Gastrointest Oncol. 2012 Dec;3(4):326-34 - PubMed
  9. J Epidemiol. 2016;26(2):64-70 - PubMed
  10. Cancer Genet. 2015 Nov;208(11):559-63 - PubMed
  11. Am J Epidemiol. 2014 Mar 15;179(6):731-9 - PubMed
  12. J Gastrointest Oncol. 2011 Sep;2(3):157-67 - PubMed
  13. J Clin Oncol. 2010 Apr 1;28(10):1645-51 - PubMed
  14. Biochim Biophys Acta. 2015 Aug;1856(1):13-27 - PubMed
  15. Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):342-6 - PubMed
  16. N Engl J Med. 2011 May 12;364(19):1817-25 - PubMed
  17. N Am J Med Sci. 2013 Jan;5(1):1-9 - PubMed
  18. IEEE Trans Biomed Eng. 2015 Jan;62(1):4-20 - PubMed
  19. Anticancer Drugs. 2000 Sep;11(8):623-8 - PubMed
  20. Pancreas. 2007 May;34(4):385-9 - PubMed
  21. World J Surg. 2013 Aug;37(8):1782-8 - PubMed
  22. Cancer Res. 2014 Jun 1;74(11):2913-21 - PubMed
  23. CA Cancer J Clin. 2011 Jul-Aug;61(4):250-81 - PubMed
  24. N Engl J Med. 2013 Oct 31;369(18):1691-703 - PubMed
  25. Ann Surg. 1999 Dec;230(6):776-82; discussion 782-4 - PubMed
  26. PLoS Med. 2010 Apr 20;7(4):e1000267 - PubMed
  27. Clin Cancer Res. 2004 Aug 1;10(15):4913-21 - PubMed
  28. J Clin Oncol. 1991 Dec;9(12):2128-33 - PubMed
  29. J Clin Oncol. 2006 Aug 20;24(24):3946-52 - PubMed
  30. J Clin Oncol. 2008 Jul 20;26(21):3503-10 - PubMed
  31. Int J Nanomedicine. 2008;3(2):133-49 - PubMed
  32. Br J Surg. 2004 May;91(5):586-94 - PubMed
  33. Lancet Oncol. 2011 Apr;12(4):353-60 - PubMed
  34. Cancer J. 2001 Jul-Aug;7(4):312-23 - PubMed
  35. Neoplasma. 2016;63(2):269-73 - PubMed
  36. Pancreas. 2016 Feb;45(2):311-6 - PubMed
  37. Cancer Chemother Pharmacol. 2013 Nov;72(5):985-90 - PubMed
  38. J Am Coll Surg. 2012 Sep;215(3):361-9 - PubMed
  39. Ann Oncol. 2003 May;14(5):675-92 - PubMed
  40. Biochim Biophys Acta. 2010 Jan;1805(1):97-104 - PubMed
  41. Br J Cancer. 2012 Jan 31;106(3):603-7 - PubMed
  42. Oncotarget. 2015 Jul 20;6(20):18162-73 - PubMed
  43. Drugs. 2014 Oct;74(15):1757-68 - PubMed
  44. Curr Oncol Rep. 2013 Apr;15(2):182-9 - PubMed
  45. Cancer. 2013 Aug 1;119(15):2692-700 - PubMed
  46. Biomed Pharmacother. 2015 Apr;71:30-6 - PubMed
  47. Br J Cancer. 2015 Apr 28;112(9):1428-34 - PubMed
  48. JAMA. 2010 Sep 8;304(10):1073-81 - PubMed
  49. Skin Pharmacol Physiol. 2006;19(1):28-37 - PubMed
  50. Gastrointest Cancer Res. 2009 Sep;3(5):208-11 - PubMed
  51. Surg Today. 2016 Feb;46(2):139-48 - PubMed
  52. Saudi J Gastroenterol. 2012 Mar-Apr;18(2):118-21 - PubMed
  53. Radiat Oncol. 2013 Jul 03;8:160 - PubMed
  54. Pancreas. 2016 Apr;45(4):503-9 - PubMed
  55. J Clin Oncol. 2011 Nov 1;29(31):4105-12 - PubMed
  56. Mol Carcinog. 2012 Jan;51(1):119-27 - PubMed
  57. JAMA. 2009 Jun 24;301(24):2553-62 - PubMed
  58. AJR Am J Roentgenol. 2007 Nov;189(5):1044-50 - PubMed
  59. Biologics. 2008 Mar;2(1):83-95 - PubMed
  60. J Clin Oncol. 2007 May 20;25(15):1960-6 - PubMed
  61. Dig Dis. 2010;28(2):355-8 - PubMed
  62. Bioelectrochemistry. 2016 Jun;109 :70-8 - PubMed
  63. Cancer Chemother Pharmacol. 2015 Aug;76(2):317-23 - PubMed
  64. Gut. 2002 Apr;50(4):549-57 - PubMed
  65. Gastroenterology. 2000 Dec;119(6):1447-53 - PubMed
  66. Technol Cancer Res Treat. 2007 Feb;6(1):37-48 - PubMed
  67. Int J Cancer. 2010 Mar 15;126(6):1474-86 - PubMed
  68. Ther Adv Med Oncol. 2015 Mar;7(2):68-84 - PubMed
  69. J Clin Oncol. 1997 Jun;15(6):2403-13 - PubMed
  70. Nat Rev Cancer. 2003 May;3(5):330-8 - PubMed
  71. Transl Oncol. 2008 Mar;1(1):36-43 - PubMed
  72. Expert Opin Investig Drugs. 2003 Jun;12(6):983-92 - PubMed
  73. Expert Opin Ther Targets. 2008 May;12(5):637-45 - PubMed

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