Display options
Cite
Amstad E, Chemama M, Eggersdorfer M, et al. Robust scalable high throughput production of monodisperse drops. Lab Chip. 2016;16(21):4163-4172doi: 10.1039/c6lc01075j.
Amstad, E., Chemama, M., Eggersdorfer, M., Arriaga, L. R., Brenner, M. P., & Weitz, D. A. (2016). Robust scalable high throughput production of monodisperse drops. Lab on a chip, 16(21), 4163-4172. https://doi.org/10.1039/c6lc01075j
Amstad, E, et al. "Robust scalable high throughput production of monodisperse drops." Lab on a chip vol. 16,21 (2016): 4163-4172. doi: https://doi.org/10.1039/c6lc01075j
Amstad E, Chemama M, Eggersdorfer M, Arriaga LR, Brenner MP, Weitz DA. Robust scalable high throughput production of monodisperse drops. Lab Chip. 2016 Oct 18;16(21):4163-4172. doi: 10.1039/c6lc01075j. PMID: 27714028.
Copy Download .nbib Format: NLM
Share it on

Lab Chip. 2016 Oct 18;16(21):4163-4172. doi: 10.1039/c6lc01075j.

Robust scalable high throughput production of monodisperse drops.

Lab on a chip

E Amstad, M Chemama, M Eggersdorfer, L R Arriaga, M P Brenner, D A Weitz

Affiliations

  1. School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA. [email protected] and Institute of Materials, Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland.
  2. School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA. [email protected].
  3. School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA. [email protected] and Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.

PMID: 27714028 DOI: 10.1039/c6lc01075j

Abstract

Monodisperse drops with diameters between 20 μm and 200 μm can be used to produce particles or capsules for many applications such as for cosmetics, food, and biotechnology. Drops composed of low viscosity fluids can be conveniently made using microfluidic devices. However, the throughput of microfluidic devices is limited and scale-up, achieved by increasing the number of devices run in parallel, can compromise the narrow drop-size distribution. In this paper, we present a microfluidic device, the millipede device, which forms drops through a static instability such that the fluid volume that is pinched off is the same every time a drop forms. As a result, the drops are highly monodisperse because their size is solely determined by the device geometry. This makes the operation of the device very robust. Therefore, the device can be scaled to a large number of nozzles operating simultaneously on the same chip; we demonstrate the operation of more than 500 nozzles on a single chip that produces up to 150 mL h

Publication Types