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Yadav R, Leviatan Ben-Arye S, Subramani B, et al. Screening of Neu5Acα(2-6)gal isomer preferences of siglecs with a sialic acid microarray. Org Biomol Chem. 2016;14(46):10812-10815doi: 10.1039/c6ob01688j.
Yadav, R., Leviatan Ben-Arye, S., Subramani, B., Padler-Karavani, V., & Kikkeri, R. (2016). Screening of Neu5Acα(2-6)gal isomer preferences of siglecs with a sialic acid microarray. Organic & biomolecular chemistry, 14(46), 10812-10815. https://doi.org/10.1039/c6ob01688j
Yadav, Rohan, et al. "Screening of Neu5Acα(2-6)gal isomer preferences of siglecs with a sialic acid microarray." Organic & biomolecular chemistry vol. 14,46 (2016): 10812-10815. doi: https://doi.org/10.1039/c6ob01688j
Yadav R, Leviatan Ben-Arye S, Subramani B, Padler-Karavani V, Kikkeri R. Screening of Neu5Acα(2-6)gal isomer preferences of siglecs with a sialic acid microarray. Org Biomol Chem. 2016 Nov 22;14(46):10812-10815. doi: 10.1039/c6ob01688j. PMID: 27714250.
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Org Biomol Chem. 2016 Nov 22;14(46):10812-10815. doi: 10.1039/c6ob01688j.

Screening of Neu5Acα(2-6)gal isomer preferences of siglecs with a sialic acid microarray.

Organic & biomolecular chemistry

Rohan Yadav, Shani Leviatan Ben-Arye, Balamurugan Subramani, Vered Padler-Karavani, Raghavendra Kikkeri

Affiliations

  1. Indian Institute of Science Education and Research, Pashan, Pune 411008, India. [email protected].
  2. Tel-Aviv University, Department of Cell Research and Immunology, Tel-Aviv, 69978 Israel. [email protected].

PMID: 27714250 DOI: 10.1039/c6ob01688j

Abstract

Sialic acids (Sias) are important terminal sugars on cell surfaces involved in a wide range of protein-carbohydrate interactions. Hence, agents modulating sias-mediated protein interactions are promising inhibitors or vaccine candidates. Here, we report the synthesis of Neu5Acα(2-6)Gal structural analogs and their binding to a series of siglecs. The results showed distinct binding patterns with conserved siglecs (hCD22 and mCD22) compared to rapid evolving siglecs (Siglecs -3 & -10).

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