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Schumacher S, Sartorius D, Ehrentreich-Förster E, et al. Miniaturization for Point-of-Care Analysis: Platform Technology for Almost Every Biomedical Assay. EJIFCC. 2012;23(3):70-5
Schumacher, S., Sartorius, D., Ehrentreich-Förster, E., & Bier, F. F. (2012). Miniaturization for Point-of-Care Analysis: Platform Technology for Almost Every Biomedical Assay. EJIFCC, 23(3), 70-5.
Schumacher, Soeren, et al. "Miniaturization for Point-of-Care Analysis: Platform Technology for Almost Every Biomedical Assay." EJIFCC vol. 23,3 (2012): 70-5.
Schumacher S, Sartorius D, Ehrentreich-Förster E, Bier FF. Miniaturization for Point-of-Care Analysis: Platform Technology for Almost Every Biomedical Assay. EJIFCC. 2012 Oct 12;23(3):70-5. eCollection 2012 Oct. PMID: 27683418; PMCID: PMC4975254.
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EJIFCC. 2012 Oct 12;23(3):70-5. eCollection 2012 Oct.

Miniaturization for Point-of-Care Analysis: Platform Technology for Almost Every Biomedical Assay.

EJIFCC

Soeren Schumacher, Dorian Sartorius, Eva Ehrentreich-Förster, Frank F Bier

PMID: 27683418 PMCID: PMC4975254

Abstract

Platform technologies for the changing need of diagnostics are one of the main challenges in medical device technology. From one point-of-view the demand for new and more versatile diagnostic is increasing due to a deeper knowledge of biomarkers and their combination with diseases. From another point-of-view a decentralization of diagnostics will occur since decisions can be made faster resulting in higher success of therapy. Hence, new types of technologies have to be established which enables a multiparameter analysis at the point-of-care. Within this review-like article a system called Fraunhofer ivD-platform is introduced. It consists of a credit-card sized cartridge with integrated reagents, sensors and pumps and a read-out/processing unit. Within the cartridge the assay runs fully automated within 15-20 minutes. Due to the open design of the platform different analyses such as antibody, serological or DNA-assays can be performed. Specific examples of these three different assay types are given to show the broad applicability of the system.

Keywords: DNA; Lab-on-a-Chip; Miniaturization; antibody; antigen

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