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Pennington KM, St Louis EK. "Don't Believe Your Eyes" Ipratropium Induced Mydriasis: A Case Report and Review of the Literature. Gen Med (Los Angel). 2016;4(3)doi: 10.4172/2327-5146.1000255.
Pennington, K. M., & St Louis, E. K. (2016). "Don't Believe Your Eyes" Ipratropium Induced Mydriasis: A Case Report and Review of the Literature. General medicine (Los Angeles, Calif.), 4(3), . https://doi.org/10.4172/2327-5146.1000255
Pennington, Kelly M, and St Louis, Erik K. ""Don't Believe Your Eyes" Ipratropium Induced Mydriasis: A Case Report and Review of the Literature." General medicine (Los Angeles, Calif.) vol. 4,3 (2016). doi: https://doi.org/10.4172/2327-5146.1000255
Pennington KM, St Louis EK. "Don't Believe Your Eyes" Ipratropium Induced Mydriasis: A Case Report and Review of the Literature. Gen Med (Los Angel). 2016 Jun;4(3). doi: 10.4172/2327-5146.1000255. Epub 2016 Jun 29. PMID: 27683661; PMCID: PMC5036352.
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Gen Med (Los Angel). 2016 Jun;4(3). doi: 10.4172/2327-5146.1000255. Epub 2016 Jun 29.

"Don't Believe Your Eyes" Ipratropium Induced Mydriasis: A Case Report and Review of the Literature.

General medicine (Los Angeles, Calif.)

Kelly M Pennington, Erik K St Louis

Affiliations

  1. Department of Internal Medicine, Mayo Clinic, Rochester, USA.
  2. Department of Neurology, Mayo Clinic, Rochester, USA.

PMID: 27683661 PMCID: PMC5036352 DOI: 10.4172/2327-5146.1000255

Abstract

Unilateral fixed mydriasis can be an ominous sign; however in many cases, it is benign and represents pharmacologic mediated action on the iris dilator or sphincter. Differentiation between pharmacologic mediated anisocoria and physiologic anisocoria can be challenging but may save on costly imaging. An 83 year-old woman was admitted with critical limb ischemia and subsequently developed respiratory failure treated with positive pressure ventilation and ipratropium nebulizers. She was noted to have left unilateral mydriasis without other neurologic deficits. Brain magnetic resonance imaging with MR angiography showed no evidence for a mass lesion or posterior communicating artery aneurysm. Her anisocoria self-resolved within 36 hours after nebulizer treatments were stopped. Ipratropium bromide is one of the most common medications used in the hospital setting and should be consider as a possible etiology when examining patients with unilateral mydriasis in the absence of other neurologic findings.

Keywords: Anisocoria; Iatrogenic; Ipratropium; Mydriasis; Pharmacology

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