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Molinari RW, Kerr C, Kerr D. Bone morphogenetic protein in pediatric spine fusion surgery. J Spine Surg. 2016;2(1):9-12doi: 10.21037/jss.2016.01.06.
Molinari, R. W., Kerr, C., & Kerr, D. (2016). Bone morphogenetic protein in pediatric spine fusion surgery. Journal of spine surgery (Hong Kong), 2(1), 9-12. https://doi.org/10.21037/jss.2016.01.06
Molinari, Robert W, et al. "Bone morphogenetic protein in pediatric spine fusion surgery." Journal of spine surgery (Hong Kong) vol. 2,1 (2016): 9-12. doi: https://doi.org/10.21037/jss.2016.01.06
Molinari RW, Kerr C, Kerr D. Bone morphogenetic protein in pediatric spine fusion surgery. J Spine Surg. 2016 Mar;2(1):9-12. doi: 10.21037/jss.2016.01.06. PMID: 27683689; PMCID: PMC5039831.
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J Spine Surg. 2016 Mar;2(1):9-12. doi: 10.21037/jss.2016.01.06.

Bone morphogenetic protein in pediatric spine fusion surgery.

Journal of spine surgery (Hong Kong)

Robert W Molinari, Christine Kerr, Danielle Kerr

Affiliations

  1. Department of Orthopaedic Surgery, University of Rochester, Rochester, New York, USA.

PMID: 27683689 PMCID: PMC5039831 DOI: 10.21037/jss.2016.01.06

Abstract

BACKGROUND: There is a paucity of literature describing the use of bone graft substitutes to achieve fusion in the pediatric spine. Outcomes and complications involving the off-label use of bone morphogenetic protein 2 (BMP-2) in the pediatric spine are not clearly defined. The purpose of this study is to review the existing literature with respect to reported outcomes and complications involving the use of low-dose BMP-2 in pediatric patients.

METHODS: A Medline and PubMed literature search was conducted using the words bone morphogenetic protein, BMP, rh-BMP-2, bone graft substitutes, and pediatric spine.

RESULTS: To date, there are few published reports on this topic. Complications and appropriate BMP-2 dosage application in the pediatric spine remain unknown.

CONCLUSIONS: This report describes the potential for BMP-2 to achieve successful arthrodesis of the spine in pediatric patients. Usage should be judicious as complications and long-term outcomes of pediatric BMP-2 usage remain undefined in the existing literature.

Keywords: Pediatric; bone morphogenetic protein (BMP); spine fusion

Conflict of interest statement

The authors have no conflicts of interest to declare.

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