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Ostadhossein F, Misra SK, Mukherjee P, et al. Defined Host-Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer. Small. 2016;12(42):5845-5861doi: 10.1002/smll.201601161.
Ostadhossein, F., Misra, S. K., Mukherjee, P., Ostadhossein, A., Daza, E., Tiwari, S., Mittal, S., Gryka, M. C., Bhargava, R., & Pan, D. (2016). Defined Host-Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer. Small (Weinheim an der Bergstrasse, Germany), 12(42), 5845-5861. https://doi.org/10.1002/smll.201601161
Ostadhossein, Fatemeh, et al. "Defined Host-Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer." Small (Weinheim an der Bergstrasse, Germany) vol. 12,42 (2016): 5845-5861. doi: https://doi.org/10.1002/smll.201601161
Ostadhossein F, Misra SK, Mukherjee P, Ostadhossein A, Daza E, Tiwari S, Mittal S, Gryka MC, Bhargava R, Pan D. Defined Host-Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer. Small. 2016 Nov;12(42):5845-5861. doi: 10.1002/smll.201601161. Epub 2016 Aug 22. PMID: 27545321; PMCID: PMC5542878.
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Small. 2016 Nov;12(42):5845-5861. doi: 10.1002/smll.201601161. Epub 2016 Aug 22.

Defined Host-Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer.

Small (Weinheim an der Bergstrasse, Germany)

Fatemeh Ostadhossein, Santosh K Misra, Prabuddha Mukherjee, Alireza Ostadhossein, Enrique Daza, Saumya Tiwari, Shachi Mittal, Mark C Gryka, Rohit Bhargava, Dipanjan Pan

Affiliations

  1. Department of Bioengineering, University of Illinois at Urbana-Champaign, 1304 W. Springfield Ave., Urbana, IL, 61801, USA.
  2. Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, PA, 16802, USA.
  3. Departments of Bioengineering, Electrical and Computer Engineering, Chemical and Biomolecular Engineering, Chemistry, and Mechanical Science and Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 1304 W. Springfield Ave., Urbana, IL, 61801, USA.
  4. Carle Foundation Hospital, 502 N. Busey St., Urbana, IL, 61801, USA.
  5. Departments of Bioengineering and Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Institute for Sustainability in Energy and Environment, 502 N. Busey St., Urbana, IL, 61801, USA.

PMID: 27545321 PMCID: PMC5542878 DOI: 10.1002/smll.201601161

Abstract

Signal transducer and activator of transcription factor 3 (STAT-3) is known to be overexpressed in cancer stem cells. Poor solubility and variable drug absorption are linked to low bioavailability and decreased efficacy. Many of the drugs regulating STAT-3 expression lack aqueous solubility; hence hindering efficient bioavailability. A theranostics nanoplatform based on luminescent carbon particles decorated with cucurbit[6]uril is introduced for enhancing the solubility of niclosamide, a STAT-3 inhibitor. The host-guest chemistry between cucurbit[6]uril and niclosamide makes the delivery of the hydrophobic drug feasible while carbon nanoparticles enhance cellular internalization. Extensive physicochemical characterizations confirm successful synthesis. Subsequently, the host-guest chemistry of niclosamide and cucurbit[6]uril is studied experimentally and computationally. In vitro assessments in human breast cancer cells indicate approximately twofold enhancement in IC

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords: STAT-3; breast cancer; host-guest chemistry; nanoparticles; vibrational spectroscopic imaging

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