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Brain Res. 2016 Oct 15;1649:90-101. doi: 10.1016/j.brainres.2016.08.023. Epub 2016 Aug 18.

Localization of nectin-2δ at perivascular astrocytic endfoot processes and degeneration of astrocytes and neurons in nectin-2 knockout mouse brain.

Brain research

Muneaki Miyata, Kenji Mandai, Tomohiko Maruo, Junya Sato, Hajime Shiotani, Aika Kaito, Yu Itoh, Shujie Wang, Takeshi Fujiwara, Akira Mizoguchi, Yoshimi Takai, Yoshiyuki Rikitake

Affiliations

  1. Division of Signal Transduction, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0047, Japan.
  2. Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0047, Japan; CREST, Japan Science and Technology Agency, Kobe, Japan.
  3. Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
  4. Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0047, Japan; Department of Neurology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
  5. CREST, Japan Science and Technology Agency, Kobe, Japan; Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.
  6. Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0047, Japan; CREST, Japan Science and Technology Agency, Kobe, Japan. Electronic address: [email protected].
  7. Division of Signal Transduction, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; CREST, Japan Science and Technology Agency, Kobe, Japan; Department of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe 658-8558, Japan. Electronic address: [email protected].

PMID: 27545667 DOI: 10.1016/j.brainres.2016.08.023

Abstract

Nectins are Ca

Copyright © 2016 Elsevier B.V. All rights reserved.

Keywords: Adhesion molecule; Astrocytes; Blood brain barrier; Endfoot; Nectin, Afadin

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