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Firoz T, Webber D, Rowe H. Drug-induced fulminant hepatic failure in pregnancy. Obstet Med. 2015;8(4):190-2doi: 10.1177/1753495X15598909.
Firoz, T., Webber, D., & Rowe, H. (2015). Drug-induced fulminant hepatic failure in pregnancy. Obstetric medicine, 8(4), 190-2. https://doi.org/10.1177/1753495X15598909
Firoz, Tabassum, et al. "Drug-induced fulminant hepatic failure in pregnancy." Obstetric medicine vol. 8,4 (2015): 190-2. doi: https://doi.org/10.1177/1753495X15598909
Firoz T, Webber D, Rowe H. Drug-induced fulminant hepatic failure in pregnancy. Obstet Med. 2015 Dec;8(4):190-2. doi: 10.1177/1753495X15598909. Epub 2015 Sep 15. PMID: 27512479; PMCID: PMC4935052.
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Obstet Med. 2015 Dec;8(4):190-2. doi: 10.1177/1753495X15598909. Epub 2015 Sep 15.

Drug-induced fulminant hepatic failure in pregnancy.

Obstetric medicine

Tabassum Firoz, Douglas Webber, Hilary Rowe

Affiliations

  1. Department of Medicine, University of British Columbia, New Westminster, BC, Canada.
  2. Department of Pathology, University of British Columbia, Vancouver, BC, Canada.
  3. Department of Pharmacy, Surrey Memorial Hospital, Surrey, BC, Canada.

PMID: 27512479 PMCID: PMC4935052 DOI: 10.1177/1753495X15598909

Abstract

Liver disease in pregnancy can be classified as predating, co-incidental or unique to pregnancy. Medications are often overlooked as a significant cause of liver disease. We present the case of a 39-year-old patient who presented at 20 weeks with jaundice, elevated liver enzymes, and abnormal liver function progressing eventually to fulminant hepatic failure. The patient was on methyldopa and labetalol from 12 weeks' gestational age. Liver biopsy was consistent with drug-induced liver injury. Both methyldopa and labetalol have been associated with hepatotoxicity including liver failure. This case highlights the importance of including medications as a cause of liver failure in pregnant patients.

Keywords: Hepatitis; drug induced; labetalol; liver dysfunction; liver failure; methyldopa

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