World J Radiol. 2016 Aug 28;8(8):743-9. doi: 10.4329/wjr.v8.i8.743.

Tumor characteristics of ductal carcinoma in situ of breast visualized on [F-18] fluorodeoxyglucose-positron emission tomography/computed tomography: Results from a retrospective study.

World journal of radiology

Tomoyuki Fujioka, Kazunori Kubota, Akira Toriihara, Youichi Machida, Kaori Okazawa, Tsuyoshi Nakagawa, Yukihisa Saida, Ukihide Tateishi

PMID: 27648168 PMCID: PMC5002505 DOI: 10.4329/wjr.v8.i8.743

Abstract

AIM: To clarify clinicopathological features of ductal carcinoma in situ (DCIS) visualized on [F-18] fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT).

METHODS: This study retrospectively reviewed 52 consecutive tumors in 50 patients with pathologically proven pure DCIS who underwent [F-18] FDG-PET/CT before surgery. [F-18] FDG-PET/CT was performed after biopsy in all patients. The mean interval from biopsy to [F-18] FDG-PET/CT was 29.2 d. [F-18] FDG uptake by visual analysis and maximum standardized uptake value (SUVmax) was compared with clinicopathological characteristics.

RESULTS: [F-18] FDG uptake was visualized in 28 lesions (53.8%) and the mean and standard deviation of SUVmax was 1.63 and 0.90. On univariate analysis, visual analysis and the SUVmax were associated with symptomatic presentation (P = 0.012 and 0.002, respectively), palpability (P = 0.030 and 0.024, respectively), use of core-needle biopsy (CNB) (P = 0.023 and 0.012, respectively), ultrasound-guided biopsy (P = 0.040 and 0.006, respectively), enhancing lesion ≥ 20 mm on magnetic resonance imaging (MRI) (P = 0.001 and 0.010, respectively), tumor size ≥ 20 mm on histopathology (P = 0.002 and 0.008, respectively). However, [F-18] FDG uptake parameters were not significantly associated with age, presence of calcification on mammography, mass formation on MRI, presence of comedo necrosis, hormone status (estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2), and nuclear grade. The factors significantly associated with visual analysis and SUVmax were symptomatic presentation (P = 0.019 and 0.001, respectively), use of CNB (P = 0.001 and 0.031, respectively), and enhancing lesion ≥ 20 mm on MRI (P = 0.001 and 0.049, respectively) on multivariate analysis.

CONCLUSION: Although DCIS of breast is generally non-avid tumor, symptomatic and large tumors (≥ 20 mm) tend to be visualized on [F-18] FDG-PET/CT.

Keywords: Breast cancer; Ductal carcinoma in situ; Positron emission tomography; [F-18] fluorodeoxyglucose-positron emission tomography/computed tomography

References

1. Clin Breast Cancer. 2014 Oct;14 (5):358-64 - PubMed
2. Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):1008-11 - PubMed
3. J Magn Reson Imaging. 2014 Mar;39(3):526-34 - PubMed
4. J Nucl Med. 2003 Aug;44(8):1238-42 - PubMed
5. J Clin Oncol. 2000 Oct 15;18(20):3495-502 - PubMed
6. Radiology. 2004 Dec;233(3):830-49 - PubMed
7. Radiology. 2013 Feb;266(2):388-405 - PubMed
8. Radiology. 2011 Jul;260(1):119-28 - PubMed
9. Am J Surg. 2009 Aug;198(2):262-9 - PubMed
10. Br J Radiol. 1999 Nov;72 (863):1064-8 - PubMed
11. Eur J Radiol. 2005 Apr;54(1):55-61 - PubMed
12. Breast Cancer Res Treat. 2011 May;127(1):1-14 - PubMed
13. Eur J Radiol. 2013 Oct;82(10):1731-7 - PubMed
14. J Nucl Med. 2006 Sep;47(9):1440-6 - PubMed
15. Radiographics. 2007 Oct;27 Suppl 1:S215-29 - PubMed
16. Ultrasound Med Biol. 2015 Jan;41(1):47-55 - PubMed
17. J Nucl Med. 2013 Jan;54(1):5-11 - PubMed
18. Breast Cancer Res Treat. 2012 Jan;131(2):357-69 - PubMed
19. CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66 - PubMed

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