Display options
Cite
Tzaneva V, Mladenova I, Todorova G, et al. Antibiotic treatment and resistance in chronic wounds of vascular origin. Clujul Med. 2016;89(3):365-70doi: 10.15386/cjmed-647.
Tzaneva, V., Mladenova, I., Todorova, G., & Petkov, D. (2016). Antibiotic treatment and resistance in chronic wounds of vascular origin. Clujul medical (1957), 89(3), 365-70. https://doi.org/10.15386/cjmed-647
Tzaneva, Valentina, et al. "Antibiotic treatment and resistance in chronic wounds of vascular origin." Clujul medical (1957) vol. 89,3 (2016): 365-70. doi: https://doi.org/10.15386/cjmed-647
Tzaneva V, Mladenova I, Todorova G, Petkov D. Antibiotic treatment and resistance in chronic wounds of vascular origin. Clujul Med. 2016;89(3):365-70. doi: 10.15386/cjmed-647. Epub 2016 Jul 28. PMID: 27547055; PMCID: PMC4990431.
Copy Download .nbib Format: NLM
Share it on

Clujul Med. 2016;89(3):365-70. doi: 10.15386/cjmed-647. Epub 2016 Jul 28.

Antibiotic treatment and resistance in chronic wounds of vascular origin.

Clujul medical (1957)

Valentina Tzaneva, Irena Mladenova, Galina Todorova, Dimitar Petkov

Affiliations

  1. MHAT Trakia, Stara Zagora, Bulgaria.
  2. Trakia University Stara Zagora, Bulgaria.

PMID: 27547055 PMCID: PMC4990431 DOI: 10.15386/cjmed-647

Abstract

BACKGROUND AND AIM: The problem of antibiotic resistance is worldwide and affects many types of pathogens. This phenomenon has been growing for decades and nowadays we are faced with a wide range of worrisome pathogens that are becoming resistant and many pathogens that may soon be untreatable. The aim of this study was to determine the resistance and antibiotic treatment in chronic wounds of vascular origin.

METHODS: We performed a cross sectional study on a sample of patients with chronic vascular wounds, hospitalized between October 2014 and August 2015, in the Clinic of Vascular Surgery in Trakia Hospital Stara Zagora. The statistical analysis of data was descriptive, considering the p value of ≤0.05, the threshold of statistical significance.

RESULTS: In the group of 110 patients, the significantly most frequent chronic wound (p<0.001) was peripheral arteriopathy (47.3%, CI95%: 38.19-56.54). Among 159 strains, 30% of patients having multiple etiology, the species most frequently isolated were Staphylococcus aureus, E.coli, Enterococcus faecalis, Pseudomonas aeruginosa and Proteus mirabilis with a significant predominance (p<0.05) of the Gram negative (55.1%). The spectrum of strains resistance included the Beta-lactams (36.4%, p<0.001), Macrolides (20%), Tetracyclines (9.1%), Aminoglycosides (8.2%) and Fluoroquinolones (4.5%).

CONCLUSIONS: Gram negative microorganisms were the main isolates in patients with vascular chronic wound. Significantly predominant was the resistance to the beta-lactam antibiotics.

Keywords: antibiotic resistance; antibiotic treatment; vascular chronic wounds

References

  1. JAMA Intern Med. 2014 Dec;174(12):1920-1 - PubMed
  2. Infect Control Hosp Epidemiol. 2003 May;24(5):362-86 - PubMed
  3. Am J Med. 1981 Feb;70(2):449-54 - PubMed
  4. J Wound Care. 2013;22(5 Suppl):S1-89 - PubMed
  5. Ann Intern Med. 1999 Aug 17;131(4):269-72 - PubMed
  6. Infect Control Hosp Epidemiol. 2005 Feb;26(2):138-43 - PubMed
  7. BMJ. 2004 Sep 4;329(7465):533 - PubMed
  8. J R Army Med Corps. 2013 Sep;159(3):237-9 - PubMed
  9. Biomed Res Int. 2013;2013:385641 - PubMed
  10. PLoS Biol. 2015 Oct 07;13(10):e1002266 - PubMed
  11. Khirurgiia (Sofiia). 2000;56(1):5-8 - PubMed

Publication Types