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Lazar MA, Vodnar D, Prodan D, et al. Antibacterial coating on biocomposites for cranio-facial reconstruction. Clujul Med. 2016;89(3):430-4doi: 10.15386/cjmed-599.
Lazar, M. A., Vodnar, D., Prodan, D., Rotaru, H., Roman, C. R., Sorcoi, L. A., Baciut, G., & Campian, R. S. (2016). Antibacterial coating on biocomposites for cranio-facial reconstruction. Clujul medical (1957), 89(3), 430-4. https://doi.org/10.15386/cjmed-599
Lazar, Madalina Anca, et al. "Antibacterial coating on biocomposites for cranio-facial reconstruction." Clujul medical (1957) vol. 89,3 (2016): 430-4. doi: https://doi.org/10.15386/cjmed-599
Lazar MA, Vodnar D, Prodan D, Rotaru H, Roman CR, Sorcoi LA, Baciut G, Campian RS. Antibacterial coating on biocomposites for cranio-facial reconstruction. Clujul Med. 2016;89(3):430-4. doi: 10.15386/cjmed-599. Epub 2016 Jul 28. PMID: 27547065; PMCID: PMC4990441.
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Clujul Med. 2016;89(3):430-4. doi: 10.15386/cjmed-599. Epub 2016 Jul 28.

Antibacterial coating on biocomposites for cranio-facial reconstruction.

Clujul medical (1957)

Madalina Anca Lazar, Dan Vodnar, Doina Prodan, Horatiu Rotaru, Calin Rares Roman, Lidia Adriana Sorcoi, Grigore Baciut, Radu Septimiu Campian

Affiliations

  1. Department of Implantology and Maxillofacial Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  2. Department of Food Science and Technology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  3. Raluca Ripan Institute for Research in Chemistry, Babes Bolyai University, Cluj-Napoca, Romania.
  4. Department of Oral and Maxillofacial Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  5. Department of Materials Science and Engineering, Technical University, Cluj-Napoca, Romania.
  6. Department of Oral Rehabilitation, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

PMID: 27547065 PMCID: PMC4990441 DOI: 10.15386/cjmed-599

Abstract

BACKGROUND AND AIMS: Despite the fact that implants are sterilized, antiseptic techniques are applied and systemic antibiotics are routinely administered prior to and after craniofacial surgery, infection rates between 3% and 40% are still reported for alloplastic implants, urging for implant removal. The present study focuses on the development of a fiber-reinforced composite (FRC) implant for craniofacial reconstruction with antimicrobial properties.

METHODS: A new fiber-reinforced composite coated with gentamicin was developed and tested for bacterial adherence and antibacterial efficiency, using two of the most involved bacterial strains in the postoperative infections: Staphylococcus aureus and Pseudomonas aeruginosa.

RESULTS: Bacteria were efficiently inactivated in direct contact with gentamicin coatings (p<0.05). The inhibition zone for Staphylococcus aureus ranged from 17.21 mm to 20.13 mm and for Pseudomonas aeruginosa ranged from 12.93 mm to 15.33 mm. Although no significant statistical results were found for bacterial adhesion and gentamicin concentration, (Staphylococcus aureus: β= -0.974; p=0.144>0.05 and Pseudomonas aeruginosa: β = -0.921; p=0.255>0.05), a negative relation was observed, indicating the reversed relation between the antibiotic dosage and the bacterial adherence.

CONCLUSION: The results of the two applied microbiological protocols used in the study suggested that gentamicin eluting coating inhibited not only the bacterial growth, but also led to a lower initial bacterial adhesion to the surface of the implant. Thus, antibiotic coating of craniofacial implants may reduce the infection rate related to reconstructive surgery.

Keywords: anti-bacterial agents; bacterial adhesion; cranial implantation

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