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Battaglini E, Liddell B, Das P, et al. Intrusive Memories of Distressing Information: An fMRI Study. PLoS One. 2016;11(9):e0140871doi: 10.1371/journal.pone.0140871.
Battaglini, E., Liddell, B., Das, P., Malhi, G., Felmingham, K., & Bryant, R. A. (2016). Intrusive Memories of Distressing Information: An fMRI Study. PloS one, 11(9), e0140871. https://doi.org/10.1371/journal.pone.0140871
Battaglini, Eva, et al. "Intrusive Memories of Distressing Information: An fMRI Study." PloS one vol. 11,9 (2016): e0140871. doi: https://doi.org/10.1371/journal.pone.0140871
Battaglini E, Liddell B, Das P, Malhi G, Felmingham K, Bryant RA. Intrusive Memories of Distressing Information: An fMRI Study. PLoS One. 2016 Sep 29;11(9):e0140871. doi: 10.1371/journal.pone.0140871. eCollection 2016. PMID: 27685784; PMCID: PMC5042442.
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PLoS One. 2016 Sep 29;11(9):e0140871. doi: 10.1371/journal.pone.0140871. eCollection 2016.

Intrusive Memories of Distressing Information: An fMRI Study.

PloS one

Eva Battaglini, Belinda Liddell, Pritha Das, Gin Malhi, Kim Felmingham, Richard A Bryant

Affiliations

  1. University of New South Wales, Sydney, Australia.
  2. University of Sydney, Sydney, Australia.
  3. University of Melbourne, Melbourne, Australia.

PMID: 27685784 PMCID: PMC5042442 DOI: 10.1371/journal.pone.0140871

Abstract

Although intrusive memories are characteristic of many psychological disorders, the neurobiological underpinning of these involuntary recollections are largely unknown. In this study we used functional magentic resonance imaging (fMRI) to identify the neural networks associated with encoding of negative stimuli that are subsequently experienced as intrusive memories. Healthy partipants (N = 42) viewed negative and neutral images during a visual/verbal processing task in an fMRI context. Two days later they were assessed on the Impact of Event Scale for occurrence of intrusive memories of the encoded images. A sub-group of participants who reported significant intrusions (n = 13) demonstrated stronger activation in the amygdala, bilateral ACC and parahippocampal gyrus during verbal encoding relative to a group who reported no intrusions (n = 13). Within-group analyses also revealed that the high intrusion group showed greater activity in the dorsomedial (dmPFC) and dorsolateral prefrontal cortex (dlPFC), inferior frontal gyrus and occipital regions during negative verbal processing compared to neutral verbal processing. These results do not accord with models of intrusions that emphasise visual processing of information at encoding but are consistent with models that highlight the role of inhibitory and suppression processes in the formation of subsequent intrusive memories.

Conflict of interest statement

The authors have declared that no competing interests exist. We confirm that Kim Felmingham is a PLOS One Editorial Board member. We also stipulate that "this does not alter our adherence to PLOS ONE

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