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Eidi A, Mortazavi P, Bazargan M, et al. Hepatoprotective activity of cinnamon ethanolic extract against CCI4-induced liver injury in rats. EXCLI J. 2012;11:495-507
Eidi, A., Mortazavi, P., Bazargan, M., & Zaringhalam, J. (2012). Hepatoprotective activity of cinnamon ethanolic extract against CCI4-induced liver injury in rats. EXCLI journal, 11495-507.
Eidi, Akram, et al. "Hepatoprotective activity of cinnamon ethanolic extract against CCI4-induced liver injury in rats." EXCLI journal vol. 11 (2012): 495-507.
Eidi A, Mortazavi P, Bazargan M, Zaringhalam J. Hepatoprotective activity of cinnamon ethanolic extract against CCI4-induced liver injury in rats. EXCLI J. 2012 Aug 20;11:495-507. eCollection 2012. PMID: 27547174; PMCID: PMC4990741.
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EXCLI J. 2012 Aug 20;11:495-507. eCollection 2012.

Hepatoprotective activity of cinnamon ethanolic extract against CCI4-induced liver injury in rats.

EXCLI journal

Akram Eidi, Pejman Mortazavi, Maryam Bazargan, Jalal Zaringhalam

Affiliations

  1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
  2. Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
  3. Department of Physiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PMID: 27547174 PMCID: PMC4990741

Abstract

The inner bark of cinnamon (Cinnamomum zeylanicum L.) is commonly used as a spice and has also been widely employed in the treatment and prevention of disease. The aim of the present study is to evaluate the protective effect of cinnamon bark extract against carbon tetrachloride (CCl4)-induced liver damage in male Wistar rats. Administration with cinnamon extracts (0.01, 0.05 and 0.1 g/kg) for 28 days significantly reduced the impact of CCl4 toxicity on the serum markers of liver damage, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase. In addition, treatment of cinnamon extract resulted in markedly increased the levels of superoxide dismutase and catalase enzymes in rats. The histopathological studies in the liver of rats also supported that cinnamon extract markedly reduced the toxicity of CCl4 and preserved the histoarchitecture of the liver tissue to near normal. Thus, the results suggest that cinnamon extract acts as a potent hepatoprotective agent against CCl4 induced hepatotoxicity in rats.

Keywords: Cinnamomum zeylanicum L.; carbon tetrachloride; cinnamon; hepatoprotective; rat

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