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Daly A, Redmond JM, Hannan MM. Culture Negative Infective Endocarditits: a Changing Paradigm. Ir Med J. 2016;109(5):409
Daly, A., Redmond, J. M., & Hannan, M. M. (2016). Culture Negative Infective Endocarditits: a Changing Paradigm. Irish medical journal, 109(5), 409.
Daly, A, et al. "Culture Negative Infective Endocarditits: a Changing Paradigm." Irish medical journal vol. 109,5 (2016): 409.
Daly A, Redmond JM, Hannan MM. Culture Negative Infective Endocarditits: a Changing Paradigm. Ir Med J. 2016 May 10;109(5):409. PMID: 27685880.
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Ir Med J. 2016 May 10;109(5):409.

Culture Negative Infective Endocarditits: a Changing Paradigm.

Irish medical journal

A Daly, J M Redmond, M M Hannan

Affiliations

  1. Department of Cardiothoracic Surgery, Mater Misercordiae University Hospital, Eccles St, Dublin 7.
  2. Department of Microbiology, Mater Misercordiae University Hospital, Eccles St, Dublin 7.

PMID: 27685880

Abstract

Traditionally, the modified Duke's criteria, based primarily on positive blood cultures, is used to diagnose Infective Endocarditis (IE). However, reports demonstrate that 31% of cases are diagnosed as Culture Negative Infective Endocarditis (CNIE)1. Consequently, empiric broad-spectrum antibiotics are prescribed to cover unidentified organisms and, as a result, antibiotic therapy may be compromised. Molecular diagnostic techniques aid with identifying causative organisms in cases of CNIE and we question if the increasing use of such technologies will change the local epidemiology of CNIE. We present the first case of Tropheryma whipplei Infective Endocarditis (TWIE) reported in Ireland.

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