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Salvador E, Burek M, Förster CY. Tight Junctions and the Tumor Microenvironment. Curr Pathobiol Rep. 2016;4:135-145doi: 10.1007/s40139-016-0106-6.
Salvador, E., Burek, M., & Förster, C. Y. (2016). Tight Junctions and the Tumor Microenvironment. Current pathobiology reports, 4135-145. https://doi.org/10.1007/s40139-016-0106-6
Salvador, Ellaine, et al. "Tight Junctions and the Tumor Microenvironment." Current pathobiology reports vol. 4 (2016): 135-145. doi: https://doi.org/10.1007/s40139-016-0106-6
Salvador E, Burek M, Förster CY. Tight Junctions and the Tumor Microenvironment. Curr Pathobiol Rep. 2016;4:135-145. doi: 10.1007/s40139-016-0106-6. Epub 2016 Jul 01. PMID: 27547510; PMCID: PMC4978755.
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Curr Pathobiol Rep. 2016;4:135-145. doi: 10.1007/s40139-016-0106-6. Epub 2016 Jul 01.

Tight Junctions and the Tumor Microenvironment.

Current pathobiology reports

Ellaine Salvador, Malgorzata Burek, Carola Y Förster

Affiliations

  1. Department of Anesthesia and Critical Care, University of Wurzburg, Oberdürrbacher Straße 6, 97080 Würzburg, Germany.

PMID: 27547510 PMCID: PMC4978755 DOI: 10.1007/s40139-016-0106-6

Abstract

PURPOSE OF REVIEW: Tight junctions (TJs) are specialized differentiations of epithelial and endothelial cell membranes. TJs play an important role in the adhesion of cells and their interaction with each other. Most cancers originate from epithelial cells. Thus, it is of significance to examine the role of TJs in the tumor microenvironment (TME) and how they affect cancer metastasis.

RECENT FINDINGS: In epithelium-derived cancers, intactness of the primary tumor mass is influenced by intercellular structures as well as cell-to-cell adhesion. Irregularities of these factors may lead to tumor dissociation and subsequent metastasis. Low expression of TJs is observed among highly metastatic cancer cells.

SUMMARY: In this review, we summarized findings from current literature in consideration of the role of TJs in relation to the TME and cancer. Deeper understanding of the mechanisms leading to TJ dysregulation is needed to facilitate the design and conceptualization of new and better therapeutic strategies for cancer.

Keywords: Cancer; Intercellular permeability; Metastasis; Tight junctions; Tumor microenvironment

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